Yokoyama S, Miyazawa T, Iitaka Y, Yamaizumi Z, Kasai H, Nishimura S
Nature. 1979 Nov 1;282(5734):107-9. doi: 10.1038/282107a0.
The hyper-modified nucleoside Q (queuosine) is exclusively located in the wobbling position of anticodons of tRNATyr tRNAHis, tRNAAsn and tRNAAsp that recognise codons NAUC (ref. 1). Queuosine and its hexose-containing derivatives are widely distributed in microorganisms, animals and plants. We confirm here the chemical structure of queuosine as 7-(3, 4-trans-4, 5-cis-dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine (Fig. 1). The unique structural features of Q are the unusual cyclopentenediol side chain and the 7-deazaguanine ring. Queuosine is one of the most complicated modified nucleosides found thus far.
超修饰核苷Q（queuosine）仅位于识别密码子NAUC的tRNATyr、tRNAHis、tRNAAsn和tRNA Asp反密码子的摆动位置（参考文献1）。Queuosine及其含己糖的衍生物广泛分布于微生物、动物和植物中。我们在此确认queuosine的化学结构为7-（3,4-反式-4,5-顺式-二羟基-1-环戊烯-3-基氨基甲基）-7-脱氮鸟苷（图1）。Q的独特结构特征是不寻常的环戊二醇侧链和7-脱氮鸟嘌呤环。Queuosine是迄今为止发现的最复杂的修饰核苷之一。
