Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Division of Cardiology, University Hospital "P. Giaccone", Palermo, Italy.
Curr Atheroscler Rep. 2024 Aug;26(8):353-366. doi: 10.1007/s11883-024-01219-1. Epub 2024 Jun 1.
This review investigates the relationship between myocardial bridges (MBs), intimal thickening in coronary arteries, and Atherosclerotic cardiovascular disease. It focuses on the role of mechanical forces, such as circumferential strain, in arterial wall remodeling and aims to clarify how MBs affect coronary artery pathology.
MBs have been identified as influential in modulating coronary artery intimal thickness, demonstrating a protective effect against thickening within the MB segment and an increase in thickness proximal to the MB. This is attributed to changes in mechanical stress and hemodynamics. Research involving arterial hypertension models and vein graft disease has underscored the importance of circumferential strain in vascular remodeling and intimal hyperplasia. Understanding the complex dynamics between MBs, mechanical strain, and vascular remodeling is crucial for advancing our knowledge of coronary artery disease mechanisms. This could lead to improved management strategies for cardiovascular diseases, highlighting the need for further research into MB-related vascular changes.
本综述研究了心肌桥（MBs）、冠状动脉内内膜增厚与动脉粥样硬化性心血管疾病之间的关系。重点探讨了机械力（如周向应变）在动脉壁重构中的作用，并旨在阐明 MBs 如何影响冠状动脉病理学。
MBs 已被确定为调节冠状动脉内膜厚度的重要因素，在 MB 节段内表现出对增厚的保护作用，并在 MB 近端增加厚度。这归因于机械应力和血液动力学的变化。涉及动脉高血压模型和静脉移植物疾病的研究强调了周向应变在血管重构和内膜增生中的重要性。理解 MB、机械应变和血管重构之间的复杂动力学对于深入了解冠状动脉疾病机制至关重要。这可能会导致心血管疾病管理策略的改进，凸显了进一步研究 MB 相关血管变化的必要性。
