Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning, China.
Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning, China.
Int J Biol Macromol. 2024 Jul;273(Pt 2):132732. doi: 10.1016/j.ijbiomac.2024.132732. Epub 2024 May 31.
One of the major diseases affecting people globally is colorectal cancer (CRC), which is primarily caused by a lack of effective medical treatment and a limited understanding of its underlying mechanisms. Cellular autophagy functions to break down and eliminate superfluous proteins and substances, thereby facilitating the continual replacement of cellular elements and generating vital energy for cell processes. Non-coding RNAs and exosomal ncRNAs have a crucial impact on regulating gene expression and essential cellular functions such as autophagy, metastasis, and treatment resistance. The latest research has indicated that specific ncRNAs and exosomal ncRNA to influence the process of autophagy in CRC cells, which could have significant consequences for the advancement and treatment of this disease. It has been determined that a variety of ncRNAs have a vital function in regulating the genes essential for the formation and maturation of autophagosomes. Furthermore, it has been confirmed that ncRNAs have a considerable influence on the signaling pathways associated with autophagy, such as those involving AMPK, AKT, and mTOR. Additionally, numerous ncRNAs have the potential to affect specific genes involved in autophagy. This study delves into the control mechanisms of ncRNAs and exosomal ncRNAs and examines how they simultaneously influence autophagy in CRC.
全球范围内，影响人们的主要疾病之一是结直肠癌（CRC），主要是由于缺乏有效的治疗方法和对其潜在机制的有限了解。细胞自噬的功能是分解和消除多余的蛋白质和物质，从而促进细胞成分的持续替换，并为细胞过程产生重要的能量。非编码 RNA 和外泌体 ncRNA 对调节基因表达和基本细胞功能（如自噬、转移和治疗抵抗）具有至关重要的影响。最新的研究表明，特定的 ncRNA 和外泌体 ncRNA 可以影响 CRC 细胞中的自噬过程，这可能对该疾病的进展和治疗产生重大影响。已经确定，多种 ncRNA 在调节形成和成熟自噬体所必需的基因方面具有重要功能。此外，已经证实 ncRNA 对与自噬相关的信号通路有很大的影响，如 AMPK、AKT 和 mTOR 信号通路。此外，许多 ncRNA 有可能影响自噬过程中涉及的特定基因。本研究深入探讨了 ncRNA 和外泌体 ncRNA 的调控机制，并研究了它们如何同时影响 CRC 中的自噬。
