外泌体非编码 RNA 在结直肠癌药物耐药中的作用
The Role of Exosomal Non-Coding RNAs in Colorectal Cancer Drug Resistance.
机构信息
Second Department of Medical Oncology, General Oncology Hospital of Kifissia "Agioi Anargiroi", 14564 Athens, Greece.
Department of Anatomy and Surgical Anatomy, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
出版信息
Int J Mol Sci. 2022 Jan 27;23(3):1473. doi: 10.3390/ijms23031473.
BACKGROUND
Colorectal cancer (CRC) is one of the most common types of cancer diagnosed worldwide with high morbidity; drug resistance is often responsible for treatment failure in CRC. Non-coding RNAs (ncRNAs) play distinct regulatory roles in tumorigenesis, cancer progression and chemoresistance.
METHODS
A literature search was conducted in PubMed database in order to sum up and discuss the role of exosomal ncRNAs (ex-ncRNAs) in CRC drug resistance/response and their possible mechanisms.
RESULTS
Thirty-six (36) original research articles were identified; these included exosome or extracellular vesicle (EV)-containing microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and small-interfering (siRNAs). No studies were found for piwi-interacting RNAs.
CONCLUSIONS
Exosomal transfer of ncRNAs has been documented as a new mechanism of CRC drug resistance. Despite being in its infancy, it has emerged as a promising field for research in order to (i) discover novel biomarkers for therapy monitoring and/or (ii) reverse drug desensitization.
背景
结直肠癌（CRC）是全球最常见的癌症类型之一，发病率较高；耐药性常常是 CRC 治疗失败的原因。非编码 RNA（ncRNA）在肿瘤发生、癌症进展和化疗耐药性中发挥着独特的调节作用。
方法
在 PubMed 数据库中进行文献检索，以总结和讨论外泌体 ncRNA（ex-ncRNA）在 CRC 耐药/反应中的作用及其可能的机制。
结果
确定了 36 篇原始研究文章；这些文章包括外泌体或细胞外囊泡（EV）中的 microRNAs（miRNAs）、长非编码 RNA（lncRNA）、环状 RNA（circRNA）和小干扰 RNA（siRNA）。没有关于 piRNA 的研究。
结论
ncRNA 的外泌体转移已被证明是 CRC 耐药性的一种新机制。尽管它还处于起步阶段，但它已经成为一个有前途的研究领域，以（i）发现用于治疗监测的新型生物标志物和/或（ii）逆转药物脱敏。
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