The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou 213003, China.
The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou 213003, China.
Carbohydr Polym. 2024 Sep 1;339:122252. doi: 10.1016/j.carbpol.2024.122252. Epub 2024 May 11.
Drug delivery technologies that could convert promising therapeutics into successful therapies have been under broad research for many years. Recently, β-glucans, natural-occurring polysaccharides extracted from many organism species such as yeast, fungi and bacteria, have attracted increasing attention to serve as drug delivery carriers. With their unique structure and innate immunocompetence, β-glucans are considered as promising carriers for targeting delivery especially when applied in the vaccine construction and oral administration of therapeutic agents. In this review, we focus on three types of β-glucans applied in the drug delivery system including yeast β-glucan, Schizophyllan and curdlan, highlighting the benefits of β-glucan based delivery system. We summarize how β-glucans as delivery vehicles have aided various therapeutics ranging from macromolecules including proteins, peptides and nucleic acids to small molecular drugs to reach desired cells or organs in terms of loading strategies. We also outline the challenges and future directions for developing the next generation of β-glucan based delivery systems.
多年来，人们一直在广泛研究药物递送技术，以期将有前途的疗法转化为成功的疗法。最近，β-葡聚糖作为一种天然存在的多糖，从酵母、真菌和细菌等多种生物物种中提取出来，作为药物递送载体引起了越来越多的关注。由于其独特的结构和先天的免疫能力，β-葡聚糖被认为是一种很有前途的靶向递药载体，特别是在疫苗构建和治疗药物的口服给药方面。在这篇综述中，我们重点介绍了三种应用于药物递送系统的β-葡聚糖，包括酵母β-葡聚糖、裂褶菌多糖和鹿角菜胶，强调了基于β-葡聚糖的递送系统的优势。我们总结了β-葡聚糖作为递送载体如何通过载药策略帮助各种治疗药物（包括蛋白质、肽和核酸等大分子以及小分子药物）到达目标细胞或器官。我们还概述了开发下一代基于β-葡聚糖的递送系统所面临的挑战和未来方向。
