State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
J Thromb Thrombolysis. 2024 Aug;57(6):1056-1066. doi: 10.1007/s11239-024-03005-x. Epub 2024 Jun 2.
Microbubble-mediated sonothrombolysis has been proven to be a non-invasive and efficient method for thrombolysis. Nevertheless, there is a potential risk that the thrombus debris generated during the dissolution of the original thrombus are too large and can lead to hazardous emboli. Using a sonothrombolysis microfluidic platform, we investigated the effects of ultrasound power, thrombolytic agent and microbubble concentration on the size of thrombus debris with the example of microbubble-mediated sonothrombolysis of arterial thrombus. Additionally, we studied the effects of ultrasound power on the size and shape of thrombus debris produced by acute and chronic arterial sonothrombolysis. In acute arterial sonothrombolysis, ultrasound power has significant effect on the size of thrombus debris and steadily increases with the increase of ultrasound power. Conversely, in chronic arterial sonothrombolysis, the size of thrombus debris is minimally affected by ultrasound power. Using the sonothrombolysis microfluidic platform, the relationship between ultrasound power and the safety of sonothrombolysis has been illustrated, and the sonothrombolysis microfluidic platform is demonstrated to be a promising tool for further studies on the process of sonothrombolysis.
超声微泡溶栓已被证明是一种非侵入性且高效的溶栓方法。然而，在溶解原有血栓的过程中产生的血栓碎片可能过大，从而导致危险栓塞，这是一个潜在的风险。本研究使用超声微泡溶栓微流控平台，以动脉血栓的超声微泡溶栓为例，研究了超声功率、溶栓药物和微泡浓度对血栓碎片大小的影响。此外，我们还研究了超声功率对急性和慢性动脉超声溶栓产生的血栓碎片大小和形状的影响。在急性动脉超声溶栓中，超声功率对血栓碎片的大小有显著影响，并随超声功率的增加而稳定增加。相反，在慢性动脉超声溶栓中，血栓碎片的大小受超声功率的影响较小。本研究使用超声微泡溶栓微流控平台，说明了超声功率与超声溶栓安全性之间的关系，表明该微流控平台是进一步研究超声溶栓过程的一种很有前途的工具。
