Shandong Provincial Key Laboratory of Plant Stress, College of Life Sciences, Shandong Normal University, Jinan 250014, China.
Shandong Provincial Key Laboratory of Plant Stress, College of Life Sciences, Shandong Normal University, Jinan 250014, China; Dongying Institute, Shandong Normal University, Dongying 257000, China.
Int J Biol Macromol. 2024 Jun;272(Pt 2):132800. doi: 10.1016/j.ijbiomac.2024.132800. Epub 2024 May 31.
CircRNAs are a class of covalently closed non-coding RNA formed by linking the 5' terminus and the 3' terminus after reverse splicing. CircRNAs are widely found in eukaryotes, and they are highly conserved, with spatio-temporal expression specificity and stability. CircRNAs can act as miRNA sponges to regulate the expression of downstream target genes, regulating the transcription of parental genes and some can even be translated into peptides or proteins. Research on circRNAs in plants is still in its infancy compared to that in animals. With the deepening of research, the results of a variety of plant circRNAs suggest that they play an important role in growth and development, and tolerance towards abiotic stresses such as salt, drought, low temperature, high temperature and other adverse environments. In this review paper, we elaborated the molecular characteristics, mechanism of action, function and bioinformatics databases of plant circRNAs, combined with the progress of circRNA research in animals, discussed the potential mechanism of action of plant circRNAs, and proposed the unsolved problems and prospects for future application of plant circRNAs.
CircRNAs 是一类通过反向剪接连接 5' 端和 3' 端形成的共价闭环非编码 RNA。CircRNAs 在真核生物中广泛存在，具有时空表达特异性和稳定性。CircRNAs 可以作为 miRNA 海绵来调节下游靶基因的表达，调节亲本基因的转录，有些甚至可以翻译成肽或蛋白质。与动物相比，植物 circRNAs 的研究仍处于起步阶段。随着研究的深入，各种植物 circRNAs 的研究结果表明，它们在生长发育以及对盐、干旱、低温、高温等不良环境的非生物胁迫的耐受中发挥着重要作用。在这篇综述论文中，我们详细阐述了植物 circRNAs 的分子特征、作用机制、功能和生物信息学数据库，结合动物 circRNA 研究的进展，讨论了植物 circRNAs 的潜在作用机制，并提出了植物 circRNAs 未来应用中尚未解决的问题和前景。
