King S J, Reilly K, Dawes J, Miller H R
Int Arch Allergy Appl Immunol. 1985;76(3):286-8. doi: 10.1159/000233707.
The appearance in blood of rat mast cell protease II (RMCPII) and glycosaminoglycan (GAG) was examined in normal and Nippostrongylus brasiliensis-primed rats challenged intravenously with worm antigen. Systemic release of these two products occurred only in immune recipients of antigen; substantial levels of RMCPII were also present in the intestinal perfusates of these same rats and there was depletion of both RMCPII and mucosal mast cells (MMC) from the intestinal mucosa. Depletion of MMC was evident after staining for proteoglycan or for serine esterase and the mast cell counts with both histochemical techniques were highly correlated. Taken together, the results suggest that MMC are likely to be the principal source of secreted GAG and RMCPII.
在正常大鼠以及用巴西日圆线虫致敏后静脉注射蠕虫抗原的大鼠中，检测了大鼠肥大细胞蛋白酶II（RMCPII）和糖胺聚糖（GAG）在血液中的出现情况。这两种产物的全身释放仅发生在接受抗原的免疫大鼠中；在这些大鼠的肠道灌流液中也存在大量的RMCPII，并且肠道黏膜中的RMCPII和黏膜肥大细胞（MMC）均有减少。用蛋白聚糖或丝氨酸酯酶染色后，MMC的减少很明显，并且两种组织化学技术的肥大细胞计数高度相关。综合来看，结果表明MMC可能是分泌型GAG和RMCPII的主要来源。
