PURPOSE: To perform a comprehensive bibliometric analysis of the application of artificial intelligence (AI) in lung disease to understand the current status and emerging trends of this field. MATERIALS AND METHODS: AI-based lung disease research publications were selected from the Web of Science Core Collection. Citespace, VOS viewer and Excel were used to analyze and visualize co-authorship, co-citation, and co-occurrence analysis of authors, keywords, countries/regions, references and institutions in this field. RESULTS: Our study included a total of 5210 papers. The number of publications on AI in lung disease showed explosive growth since 2017. China and the United States lead in publication numbers. The most productive author were Li, Weimin and Qian Wei, with Shanghai Jiaotong University as the most productive institution. Radiology was the most co-cited journal. Lung cancer and COVID-19 emerged as the most studied diseases. Deep learning, convolutional neural network, lung cancer, radiomics will be the focus of future research. CONCLUSIONS: AI-based diagnosis and treatment of lung disease has become a research hotspot in recent years, yielding significant results. Future work should focus on establishing multimodal AI models that incorporate clinical, imaging and laboratory information. Enhanced visualization of deep learning, AI-driven differential diagnosis model for lung disease and the creation of international large-scale lung disease databases should also be considered.