Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Epidemiology of Aging, National Centre for Geriatrics and Gerontology, Obu, Japan.
Geriatr Gerontol Int. 2024 Jul;24(7):700-705. doi: 10.1111/ggi.14916. Epub 2024 Jun 3.
Several studies have shown that dairy consumption in old age is effective in preventing frailty. However, there is a lack of evidence regarding the association between milk consumption during middle age and the development of frailty in old age. Therefore, we carried out an investigation to explore the association between milk consumption during middle age and development of frailty examined after over 15 years of follow up in a long-term cohort study in Japan.
We studied 265 participants aged 60-79 years (212 men and 53 women) in 2018, who participated in both the baseline survey in 2002 and the frailty assessment in 2018. The amount of milk consumption (g/day) at baseline was age- and energy-adjusted, and classified into three categories (no, low and high consumption: 0 g/day, ≤135.86 g/day, >135.86 g/day in men and 0 g/day, ≤126.44 g/day, >126.44 g/day in women). Odds ratios (OR) and 95% confidence intervals (CI) for prefrailty/frailty after adjusting for lifestyles at baseline, stratified by sex, were estimated using logistic regression analysis.
The prevalence of prefrailty/frailty in 2018 was 37.7% and 28.3% in men and women, respectively. Milk consumption categories were inversely associated with the prevalence of prefrailty/frailty in men (OR 0.34, 95% CI 0.14-0.84 in low consumption; OR 0.31, 95% CI 0.10-0.95 in high consumption; P < 0.05), but not in women (OR 0.53, 95% CI 0.11-2.65; P = 0.44).
In this study, milk intake in middle-aged men was inversely associated with the prevalence of prefrailty/frailty later in life. Geriatr Gerontol Int 2024; 24: 700-705.
多项研究表明，老年人摄入乳制品可有效预防虚弱。然而，目前尚缺乏关于中年期摄入牛奶与老年期发生虚弱之间关联的证据。因此，我们开展了一项研究，旨在通过在日本一项长期队列研究中进行超过 15 年的随访，调查中年期摄入牛奶与之后发生虚弱之间的关系。
我们研究了 2018 年参加基线调查（2002 年）和虚弱评估（2018 年）的 265 名年龄在 60-79 岁的参与者（212 名男性和 53 名女性）。以年龄和能量校正后的基线牛奶摄入量（g/天），并分为 3 类（不摄入、低摄入和高摄入：男性 0g/天，≤135.86g/天，>135.86g/天；女性 0g/天，≤126.44g/天，>126.44g/天）。采用 logistic 回归分析，按性别分层，对调整基线生活方式后的虚弱前期/虚弱的比值比（OR）及其 95%置信区间（CI）进行估计。
2018 年男性和女性的虚弱前期/虚弱发生率分别为 37.7%和 28.3%。在男性中，牛奶摄入量与虚弱前期/虚弱的发生率呈负相关（低摄入量组 OR 0.34，95%CI 0.14-0.84；高摄入量组 OR 0.31，95%CI 0.10-0.95；P<0.05），但在女性中无此关联（OR 0.53，95%CI 0.11-2.65；P=0.44）。
在这项研究中，中年男性摄入牛奶与晚年虚弱前期/虚弱的发生率呈负相关。
