Institute of Laboratory Animal Science, University Zurich, Wagistr. 12, 8952 Schlieren, Zurich, Switzerland.
Department of General, Visceral and Transplant Surgery, Experimental Surgical Endoscopy, University Hospital Tübingen, Tübingen, Germany.
J Mol Med (Berl). 2024 Aug;102(8):1009-1013. doi: 10.1007/s00109-024-02457-1. Epub 2024 Jun 3.
In this work, for the first time, the specific impedances of various injection solutions as well as the surface and tissue impedance after injection of these solutions were analyzed and compared regarding the radio-frequency surgical cutting process. The impedances of 0.9% NaCl, 4% gelatine, 6% hydroxyethyl starch, 10% glycerol/5% fructose, 10% glucose, 5% and 20% albumin, blood, and blood plasma as well as aqua destillata have been tested in vitro. Even if EMR and ESD are routinely used in clinical practice, there is so far no easy, fast, and safe method to remove larger lesions en bloc. We show that the impedance of the injected solution shows to be a crucial factor for safe removal, especially of larger lesions (Ø > 20 mm) and more importantly in accordance with the requirements of oncology and pathology. KEY MESSAGES: Impedance is playing a crucial factor in the radio-frequency (RF)-surgery. With a higher Impedance there will be less current necessary to reach the aimed voltage. Injection solution Aqua destillata and 10% Glucose, show significantly higher Impedances. Higher impedances lead to less surgical related complications. Minor changes in existing method to improve patent safety.
在这项工作中，首次分析和比较了各种注射溶液的具体阻抗以及注射这些溶液后的表面和组织阻抗，涉及射频手术切割过程。在体外测试了 0.9%NaCl、4%明胶、6%羟乙基淀粉、10%甘油/5%果糖、10%葡萄糖、5%和 20%白蛋白、血液和血浆以及蒸馏水的阻抗。即使 EMR 和 ESD 在临床实践中常规使用，但迄今为止，还没有一种简单、快速和安全的方法可以整块切除较大的病变。我们表明，注入溶液的阻抗是安全去除的关键因素，特别是对于较大的病变（Ø > 20mm），更重要的是符合肿瘤学和病理学的要求。关键信息：阻抗在射频 (RF) 手术中起着至关重要的作用。阻抗越高，达到目标电压所需的电流就越小。注射溶液蒸馏水和 10%葡萄糖的阻抗明显较高。较高的阻抗导致较少的手术相关并发症。对现有方法进行微小改变以提高专利安全性。
