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用细菌磷脂保护小鼠免受蛙病毒3(FV 3)致死效应的影响(作者译)

[Protection of mice with bacterial phospholipids against the lethal effect of Frog Virus 3 (FV 3) (author's transl)].

作者信息

Anton M, Kirn A

出版信息

Pathol Biol (Paris). 1979 May;27(5):269-73.

PMID:388298
Abstract

A bacterial phospholipid extract (EBP) inoculated intraveinously at a dose of 1 mg/25 g body weight 30 hours before infection protects mice against the lethal effect of Frog Virus 3 (FV 3). The anti-FV 3 resistance produced by EBP requires protein synthesis during the period of pretreatment. The treatment with the bacterial extract has no effect on the inhibition of the macromolecular synthesis of the liver (RNA and DNA) which is observed at the beginning of the infection. However 48 hours after FV 3 infection, there is a notable stimulation of DNA synthesis which probably corresponds to liver regeneration.

摘要

在感染前30小时以1毫克/25克体重的剂量静脉注射细菌磷脂提取物(EBP)可保护小鼠免受蛙病毒3(FV 3)的致死作用。EBP产生的抗FV 3抗性在预处理期间需要蛋白质合成。细菌提取物处理对感染开始时观察到的肝脏大分子合成(RNA和DNA)的抑制没有影响。然而,在FV 3感染48小时后,DNA合成有明显的刺激,这可能与肝脏再生相对应。

相似文献

1
[Protection of mice with bacterial phospholipids against the lethal effect of Frog Virus 3 (FV 3) (author's transl)].用细菌磷脂保护小鼠免受蛙病毒3(FV 3)致死效应的影响(作者译)
Pathol Biol (Paris). 1979 May;27(5):269-73.
2
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