Alesenko A V, Boĭkov P Ia, Burlakova E B, Krasil'nikov V A, Sidorenko L I
Biokhimiia. 1978 Nov;43(11):1966-72.
After a drastic inhibition of protein synthesis (95%) in rat liver by cycloheximide (0.2-0.4 mg/100 g of body weight) the recovery and subsequently prolonged marked stimulation of proteins, lipids and DNA were found. The correlation of nuclear membrane proteins and lipids synthesis was observed in a recovery and stimulation phases. Nuclear DNA synthesis increases after the stimulation biosynthesis of nuclear membrane components (36-40 hours after cycloheximide injection). The changes of a phospholipid composition and structure organisation of nuclear membrane hydrophobic zones (by spin probe) were found in stimulated DNA synthesis (48-60 hours).
在用放线菌酮（0.2 - 0.4毫克/100克体重）对大鼠肝脏蛋白质合成进行强烈抑制（95%）后，发现蛋白质、脂质和DNA随后出现恢复并持续长时间的显著刺激。在恢复和刺激阶段观察到核膜蛋白质与脂质合成的相关性。在核膜成分生物合成受到刺激后（放线菌酮注射后36 - 40小时），核DNA合成增加。在刺激DNA合成过程中（48 - 60小时），发现核膜疏水区域的磷脂组成和结构组织发生了变化（通过自旋探针）。
