Bibi Alessia, Bartekova Monika, Gandhi Shrey, Greco Simona, Madè Alisia, Sarkar Moumita, Stopa Victoria, Tastsoglou Spyros, de Gonzalo-Calvo David, Devaux Yvan, Emanueli Costanza, Hatzigeorgiou Artemis G, Nossent A Yaël, Zhou Zhichao, Martelli Fabio
Molecular Cardiology Laboratory, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Department of Biosciences, University of Milan, Milan, Italy.
Br J Pharmacol. 2025 Jan;182(2):316-339. doi: 10.1111/bph.16434. Epub 2024 Jun 3.
Cardiac remodelling involves structural, cellular and molecular alterations in the heart after injury, resulting in progressive loss of heart function and ultimately leading to heart failure. Circular RNAs (circRNAs) are a recently rediscovered class of non-coding RNAs that play regulatory roles in the pathogenesis of cardiovascular diseases, including heart failure. Thus, a more comprehensive understanding of the role of circRNAs in the processes governing cardiac remodelling may set the ground for the development of circRNA-based diagnostic and therapeutic strategies. In this review, the current knowledge about circRNA origin, conservation, characteristics and function is summarized. Bioinformatics and wet-lab methods used in circRNA research are discussed. The regulatory function of circRNAs in cardiac remodelling mechanisms such as cell death, cardiomyocyte hypertrophy, inflammation, fibrosis and metabolism is highlighted. Finally, key challenges and opportunities in circRNA research are discussed, and orientations for future work to address the pharmacological potential of circRNAs in heart failure are proposed. LINKED ARTICLES: This article is part of a themed issue Non-coding RNA Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v182.2/issuetoc.
心脏重塑涉及损伤后心脏的结构、细胞和分子改变，导致心脏功能逐渐丧失，最终导致心力衰竭。环状RNA（circRNAs）是最近重新发现的一类非编码RNA，在包括心力衰竭在内的心血管疾病发病机制中发挥调节作用。因此，更全面地了解circRNAs在心脏重塑过程中的作用可能为基于circRNAs的诊断和治疗策略的开发奠定基础。在这篇综述中，总结了关于circRNA起源、保守性、特征和功能的当前知识。讨论了circRNA研究中使用的生物信息学和湿实验室方法。强调了circRNAs在细胞死亡、心肌细胞肥大、炎症、纤维化和代谢等心脏重塑机制中的调节功能。最后，讨论了circRNA研究中的关键挑战和机遇，并提出了未来工作的方向，以探讨circRNAs在心力衰竭中的药理学潜力。相关文章：本文是主题为“非编码RNA治疗学”的一部分。要查看本节中的其他文章，请访问http://onlinelibrary.wiley.com/doi/10.1111/bph.v182.2/issuetoc。
