Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Funct Integr Genomics. 2024 May 17;24(3):102. doi: 10.1007/s10142-024-01386-z.
Cardiovascular disease, specifically heart failure (HF), remains a significant concern in the realm of healthcare, necessitating the development of new treatments and biomarkers. The RNA family consists of various subgroups, including microRNAs, PIWI-interacting RNAs (piRAN) and long non-coding RNAs, which have shown potential in advancing personalized healthcare for HF patients. Recent research suggests that circular RNAs, a lesser-known subgroup of RNAs, may offer a novel set of targets and biomarkers for HF. This review will discuss the biogenesis of circular RNAs, their unique characteristics relevant to HF, their role in heart function, and their potential use as biomarkers in the bloodstream. Furthermore, future research directions in this field will be outlined. The stability of exosomal circRNAs makes them suitable as biomarkers, pathogenic regulators, and potential treatments for cardiovascular diseases such as atherosclerosis, acute coronary syndrome, ischemia/reperfusion injury, HF, and peripheral artery disease. Herein, we summarized the role of circular RNAs and their exosomal forms in HF diseases.
心血管疾病，特别是心力衰竭（HF），仍然是医疗保健领域的一个重大关注点，需要开发新的治疗方法和生物标志物。RNA 家族包括多种亚群，如 microRNAs、PIWI 相互作用 RNA（piRAN）和长非编码 RNA，它们在推进 HF 患者的个性化医疗方面显示出了潜力。最近的研究表明，环状 RNA，一种鲜为人知的 RNA 亚群，可能为 HF 提供一组新的靶点和生物标志物。本综述将讨论环状 RNA 的生物发生、它们与 HF 相关的独特特征、它们在心脏功能中的作用，以及它们作为血液生物标志物的潜在用途。此外，还将概述该领域的未来研究方向。外泌体 circRNAs 的稳定性使它们成为生物标志物、致病调节剂以及动脉粥样硬化、急性冠状动脉综合征、缺血/再灌注损伤、HF 和外周动脉疾病等心血管疾病的潜在治疗方法的理想选择。本文总结了环状 RNA 及其外泌体形式在 HF 疾病中的作用。
