Department of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, 1601 Trinity Street, Austin, TX 78712, United States.
Department of Psychiatry and Behavioral Sciences, The University of Texas at Austin Dell Medical School, 1601 Trinity Street, Austin, TX 78712, United States.
Psychiatry Res. 2024 Aug;338:115980. doi: 10.1016/j.psychres.2024.115980. Epub 2024 May 27.
Comorbidity between post-traumatic stress disorder (PTSD) and substance use disorder may be explained by a prospective trauma risk conferred by both conditions. The current study modeled concurrent and prospective associations of trauma, PTSD symptoms, and substance use (SU) behavior among trauma exposed youth (ages 8-20). Clinical interviews assessed trauma exposure, PTSD symptom severity, and SU behavior at baseline and at six- and 12-month follow up study visits (N = 2,069). Structural equation models assessed the associations of trauma, PTSD symptoms, and SU behavior. Lifetime trauma was associated with more severe PTSD symptoms and SU behaviors, whereas trauma exposure during the study was only associated with PTSD symptoms. PTSD symptom severity was prospectively associated with trauma exposure. PTSD symptom severity and SU behavior at follow-up study visits were prospectively associated. These results highlight the dynamic interplay between trauma, PTSD symptoms, and SU behavior during youth, a developmental period during which complex psychiatric presentations can have longstanding consequences for health.
创伤后应激障碍 (PTSD) 和物质使用障碍之间的共病可能可以通过这两种情况带来的前瞻性创伤风险来解释。本研究通过对创伤暴露的青年（8-20 岁）进行同期和前瞻性研究，建立了创伤、PTSD 症状和物质使用 (SU) 行为之间的模型。临床访谈在基线和 6 个月及 12 个月的随访研究访问中评估了创伤暴露、PTSD 症状严重程度和 SU 行为（N=2069）。结构方程模型评估了创伤、PTSD 症状和 SU 行为之间的关联。终生创伤与更严重的 PTSD 症状和 SU 行为有关，而研究期间的创伤暴露仅与 PTSD 症状有关。PTSD 症状严重程度与创伤暴露呈前瞻性相关。随访研究访问中的 PTSD 症状严重程度和 SU 行为呈前瞻性相关。这些结果强调了青少年时期创伤、PTSD 症状和 SU 行为之间的动态相互作用，这是一个发展时期，复杂的精神表现可能会对健康产生长期影响。
