Seidel W, Hecker M, Wagner U, Häntzschel H
Abteilung Rheumatologie, Medizinische Klinik IV, Universität Leipzig, Liebigstrasse 22, 04103 Leipzig, Deutschland.
Z Rheumatol. 2006 Oct;65(6):482, 484-6. doi: 10.1007/s00393-006-0103-y.
Rheumatoid arthritis is associated with increased morbidity and mortality due to cardiovascular events. Elevated concentrations of acute-phase proteins and cytokines and endothelial dysfunction, demonstrated also by lack of traditional risk factors, play an important role in these complications. Antirheumatic drug treatment can modify the frequency and severity of cardiovascular events.
类风湿性关节炎与心血管事件导致的发病率和死亡率增加有关。急性期蛋白和细胞因子浓度升高以及内皮功能障碍(传统危险因素缺乏时也可表现出来)在这些并发症中起重要作用。抗风湿药物治疗可改变心血管事件的发生频率和严重程度。