Frank F, Gaist G, Piazza G, Ricci R F, Sturiale C, Galassi E
Surg Neurol. 1985 Mar;23(3):275-80. doi: 10.1016/0090-3019(85)90095-3.
Stereotaxic biopsy was performed in 10 patients with tumors of the pineal region. On the basis of intraoperative tissue diagnosis, low-energy radioactive sources (125I) were implanted in seven patients for interstitial irradiation during the same stereotaxic procedure. Results were good in five cases. This therapeutic modality appears to be indicated in cases of proven low-grade malignancy, inasmuch as the implantation of radioactive sources in a highly malignant lesion carries the risk of severe, often irreversible, damage to the surrounding brain, because of possible seed migration.
对10例松果体区肿瘤患者进行了立体定向活检。根据术中组织诊断，在同一立体定向手术过程中，对7例患者植入低能量放射源（125I）进行间质内照射。5例效果良好。这种治疗方式似乎适用于已证实为低度恶性的病例，因为在高度恶性病变中植入放射源存在因可能的籽源迁移而对周围脑组织造成严重且往往不可逆损伤的风险。
