Amini Amin, Schmidt Richard H, Salzman Karen L, Chin Steven S, Couldwell William T
Department of Neurosurgery, University of Utah School of Medicine, Suite 3B409, 30 North 1900 East, Salt Lake City, UT 84132-2303, USA.
J Neurooncol. 2006 Sep;79(3):307-14. doi: 10.1007/s11060-006-9145-x. Epub 2006 Apr 28.
Glioblastoma multiforme (GBMs) tumors are exceedingly rare tumors in the pineal region. We present three cases in which patients presented with a pineal/posterior third ventricular region mass and review all the previously reported cases in the literature. Pineal region GBM seems to be a very aggressive tumor with a high rate of leptomeningeal and ependymal metastatic disease. Patients usually present with signs and symptoms of hydrocephalus and Parinaud's syndrome. The clinical and radiological characteristics of pineal GBM do not differentiate it from other malignancies of this region, thus surgical biopsy is generally required for definitive diagnosis. Glioblastoma should be considered in the differential diagnosis of the pineal region tumors, especially when evidence of leptomeningeal or ependymal metastatic disease is present.
多形性胶质母细胞瘤（GBMs）是松果体区域极为罕见的肿瘤。我们报告了3例患者，这些患者均表现为松果体/第三脑室后部区域肿块，并回顾了文献中所有先前报道的病例。松果体区域的GBM似乎是一种极具侵袭性的肿瘤，软脑膜和室管膜转移疾病的发生率很高。患者通常表现出脑积水和帕里诺德综合征的体征和症状。松果体GBM的临床和放射学特征与该区域的其他恶性肿瘤并无差异，因此通常需要进行手术活检以明确诊断。在松果体区域肿瘤的鉴别诊断中应考虑胶质母细胞瘤，尤其是当存在软脑膜或室管膜转移疾病的证据时。
