Wozny David, Nguyen Minh Thu T, Kumar Shruti Adidam, Schoenfeld Adam
Department of Internal Medicine, University of Connecticut, Farmington, CT.
Department of Gastroenterology and Hepatology, University of Connecticut, Farmington, CT.
ACG Case Rep J. 2024 Jun 3;11(6):e01367. doi: 10.14309/crj.0000000000001367. eCollection 2024 Jun.
Anal mucinous adenocarcinoma arises from mucin-secreting columnar epithelium within anal glands and is extremely rare, comprising 2%-3% of all gastrointestinal malignancies. We present a unique case of 65-year-old developmentally disabled man with complaint of rectal pain. Examination showed an excoriated erythematous perianal region with mucinous film and subdermal nodularity. Surgical pathology of the lesion revealed poorly differentiated mucinous adenocarcinoma of intestinal type. Subsequent colonoscopy was without findings of intraluminal lesions. He established with oncology and later underwent a positron emission tomography scan that showed extensive metastasis. This case highlights a unique presentation of mucinous adenocarcinoma with luminal sparing.
肛管黏液腺癌起源于肛管腺内分泌黏液的柱状上皮，极为罕见，占所有胃肠道恶性肿瘤的2% - 3%。我们报告一例独特病例，患者为一名65岁的发育障碍男性，主诉直肠疼痛。检查发现肛周区域有擦伤、红斑，伴有黏液膜和皮下结节。病变的手术病理显示为低分化肠型黏液腺癌。随后的结肠镜检查未发现腔内病变。他转诊至肿瘤科，后来接受了正电子发射断层扫描，结果显示有广泛转移。该病例突出了黏液腺癌一种腔内未受累的独特表现。
