Tippett Donna C, Neophytou Kyriaki, Tao Yuan, Gallegos Jessica, Morrow Christopher, Onyike Chiadi U, Tsapkini Kyrana
Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
J Cent Nerv Syst Dis. 2024 Jun 3;16:11795735241258435. doi: 10.1177/11795735241258435. eCollection 2024.
We present the case of a 62-year-old woman with probable behavioral variant of frontotemporal dementia (bvFTD) with cognitive/language deficits who demonstrated improved performance on cognitive/language testing and in functional tasks following long-term, home-based transcranial direct current stimulation (tDCS) coupled with computerized cognitive training (CCT). The patient underwent home-based tDCS (anode on the left prefrontal cortex and cathode on the right homologue) for 46 sessions over 10 weeks along with CCT. On post-treatment testing, the patient improved by 3 points on the Mini-Mental State Exam (MMSE) (23 to 26). She also showed improvement on several cognitive/language tasks, such as immediate recall of single words and word pairs, total accurate words in sentence repetition, delayed recall, semantic processing, and sentence level comprehension. There was no decline in several other cognitive and language tasks. Family members reported subjective improvements in expressiveness, communication, and interaction with others as well as increased attention to grooming and style which contrasted with her pre-treatment condition. This report suggests that home-based tDCS combined with CCT for an extended period may slow decline, and improve cognitive/language performance and everyday function in FTD.
我们报告了一例62岁女性，患有可能为行为变异型额颞叶痴呆（bvFTD）且伴有认知/语言缺陷，在长期居家经颅直流电刺激（tDCS）联合计算机化认知训练（CCT）后，其认知/语言测试及功能任务表现有所改善。该患者在10周内接受了46次居家tDCS（阳极置于左侧前额叶皮质，阴极置于右侧对应部位）并同时进行CCT。治疗后测试显示，患者简易精神状态检查表（MMSE）得分提高了3分（从23分提高到26分）。她在多项认知/语言任务上也有改善，如单个单词和单词对的即时回忆、句子重复中的准确单词总数、延迟回忆、语义处理以及句子层面的理解。其他多项认知和语言任务并未下降。家庭成员报告称，与治疗前相比，患者在表达能力、沟通能力、与他人互动方面有主观改善，对修饰和风格的关注也有所增加。本报告表明，长期居家tDCS联合CCT可能会减缓衰退，并改善FTD患者的认知/语言表现及日常功能。
