Shang Zhizhong, Wanyan Pingping, Wang Mingchuan, Zhang Baolin, Cui Xiaoqian, Wang Xin
The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Department of Pathology and Pathophysiology, School of Basic Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, China.
Front Pharmacol. 2023 Jul 18;14:1235324. doi: 10.3389/fphar.2023.1235324. eCollection 2023.
This study aimed to conduct a bibliometric analysis of the literature on stem cell therapy for spinal cord injury to visualize the research status, identify hotspots, and explore the development trends in this field. We searched the Web of Science Core Collection database using relevant keywords ("stem cells" and "spinal cord injury") and retrieved the published literature between 2000 and 2022. Data such as journal title, author information, institutional affiliation, country, and keywords were extracted. Afterwards, we performed bibliometric analysis of the retrieved data using Bibliometrix, VOSviewer, and CiteSpace. A total of 5375 articles related to stem cell therapy for spinal cord injury were retrieved, and both the annual publication volume and the cumulative publication volume showed an upward trend. neural regeneration research was the journal with the most publications and the fastest cumulative publication growth (162 articles), Okano Hideyuki was the author with the highest number of publications and citations (114 articles), Sun Yat-sen University was the institution with the highest number of publications (420 articles), and China was the country with the highest number of publications (5357 articles). However, different authors, institutions, and countries need to enhance their cooperation in order to promote the generation of significant academic achievements. Current research in this field has focused on stem cell transplantation, neural regeneration, motor function recovery, exosomes, and tissue engineering. Meanwhile, future research directions are primarily concerned with the molecular mechanisms, safety, clinical trials, exosomes, scaffolds, hydrogels, and inflammatory responses of stem cell therapy for spinal cord injuries. In summary, this study provided a comprehensive analysis of the current research status and frontiers of stem cell therapy for spinal cord injury. The findings provide a foundation for future research and clinical translation efforts of stem cell therapy in this field.
本研究旨在对脊髓损伤干细胞治疗的文献进行文献计量分析，以可视化研究现状、识别热点并探索该领域的发展趋势。我们使用相关关键词（“干细胞”和“脊髓损伤”）在科学网核心合集数据库中进行检索，并检索了2000年至2022年期间发表的文献。提取了期刊名称、作者信息、机构隶属关系、国家和关键词等数据。之后，我们使用Bibliometrix、VOSviewer和CiteSpace对检索到的数据进行文献计量分析。共检索到5375篇与脊髓损伤干细胞治疗相关的文章，年发表量和累积发表量均呈上升趋势。《神经再生研究》是发表文章最多且累积发表增长最快的期刊（162篇），冈野英之是发表文章数量和被引次数最多的作者（114篇），中山大学是发表文章数量最多的机构（420篇），中国是发表文章数量最多的国家（5357篇）。然而，不同的作者、机构和国家需要加强合作，以促进重大学术成果的产生。该领域目前的研究集中在干细胞移植、神经再生、运动功能恢复、外泌体和组织工程。同时，未来的研究方向主要涉及脊髓损伤干细胞治疗的分子机制、安全性、临床试验、外泌体、支架、水凝胶和炎症反应。总之，本研究对脊髓损伤干细胞治疗的当前研究现状和前沿进行了全面分析。研究结果为该领域干细胞治疗的未来研究和临床转化工作提供了基础。
