Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Medical University General Hospital, Tianjin, China; Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Medical University General Hospital, Tianjin, China.
Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Medical University General Hospital, Tianjin, China; Tianjin Key Laboratory of Spine and Spinal Cord Injury, Tianjin Medical University General Hospital, Tianjin, China.
World Neurosurg. 2024 Jun;186:e95-e105. doi: 10.1016/j.wneu.2024.03.048. Epub 2024 Mar 18.
This study aimed to conduct a bibliometric analysis of the literature on hydrogel therapy for spinal cord injury to visualize the research status, identify hotspots, and explore the development trends in this field.
Web of science Core Collection database was searched for relevant studies published between January 1991 and December 2023. Data such as journal title, author information, institutional affiliation, country, citation, and keywords were extracted. Bibliometrix, CiteSpace, and VOSviewer were used to perform bibliometric analysis of the retrieved data.
A total of 1099 articles pertaining to hydrogel therapy for spinal cord injury were retrieved, revealing an upward trajectory in both annual publication volume and cumulative publication volume. Biomaterials emerged as the journal with the highest number of publications and the most rapid cumulative publication growth, contributing 84 articles. Among authors, Shoichet MS stood out with the highest number of publications and citations, totaling 66 articles. The University of Toronto led in institutional contributions with 65 publications, while China dominated in country-specific publications, accounting for 374 articles. However, to foster significant academic achievements, it is imperative for diverse authors, institutions, and countries to enhance collaboration. Current research in this field concentrates on scaffold architecture, nerve growth factor, the fibrotic microenvironment, and guidance channels. Simultaneously, upcoming research directions prioritize 3D bioprinting, injectable hydrogel, inflammation, and nanoparticles within the realm of hydrogel therapy for spinal cord injuries.
In summary, this study provided a comprehensive analysis of the current research status and frontiers of hydrogel therapy for spinal cord injury. The findings provide a foundation for future research and clinical translation efforts of hydrogel therapy in this field.
本研究旨在对水凝胶治疗脊髓损伤的文献进行计量学分析，以可视化研究现状，确定热点，并探讨该领域的发展趋势。
在 1991 年 1 月至 2023 年 12 月期间，通过 Web of Science 核心合集数据库检索了相关研究。提取了期刊名称、作者信息、机构隶属关系、国家、引文和关键词等数据。使用 Bibliometrix、CiteSpace 和 VOSviewer 对检索到的数据进行了计量学分析。
共检索到 1099 篇关于水凝胶治疗脊髓损伤的文章，其年度发文量和累积发文量均呈上升趋势。生物材料是发文量最高和累积发文增长最快的期刊，共发表了 84 篇文章。在作者中，Shoichet MS 的发文量和被引频次最高，总计 66 篇。多伦多大学在机构贡献方面排名第一，有 65 篇文章，而中国在特定国家的发文量方面处于领先地位，占 374 篇。然而，为了取得重大的学术成就，不同的作者、机构和国家必须加强合作。目前该领域的研究重点是支架结构、神经生长因子、纤维性微环境和导向通道。同时，水凝胶治疗脊髓损伤的未来研究方向包括 3D 生物打印、可注射水凝胶、炎症和纳米粒子。
综上所述，本研究全面分析了水凝胶治疗脊髓损伤的研究现状和前沿领域。研究结果为水凝胶治疗在该领域的未来研究和临床转化提供了基础。
