Department of Psychology, The Chinese University of Hong Kong, Shatin, Hong Kong.
Research Centre for Neuropsychological Well-Being, The Chinese University of Hong Kong, Shatin, Hong Kong.
Alzheimers Dement. 2024 Aug;20(8):5170-5182. doi: 10.1002/alz.13897. Epub 2024 Jun 5.
Identifying individuals at risk of developing dementia is crucial for early intervention. Mild cognitive impairment (MCI) and subjective memory complaints (SMCs) are considered its preceding stages. This study aimed to assess the utility of functional near-infrared spectroscopy (fNIRS) in identifying individuals with MCI and SMC.
One hundred fifty-one participants were categorized into normal cognition (NC); amnestic MCI (aMCI); non-amnestic MCI (naMCI); and mild, moderate, and severe SMC groups. Task-related prefrontal hemodynamics were measured using fNIRS during a visual memory span task.
Results showed significantly lower oxyhemoglobin (HbO) levels in aMCI, but not in naMCI, compared to the NC. In addition, severe SMC had lower HbO levels than the NC, mild, and moderate SMC. Receiver operating characteristic analysis demonstrated 69.23% and 69.70% accuracy in differentiating aMCI and severe SMC from NC, respectively.
FNIRS may serve as a potential non-invasive biomarker for early detection of dementia.
Only amnestic mild cognitive impairment (aMCI), but not non-amnestic MCI, showed lower oxyhemoglobin (HbO) than normal individuals. Reduced HbO was observed in those with severe subjective memory complaints (SMCs) compared to normal cognition (NC), mild, and moderate SMCs. Functional near-infrared spectroscopy measures were associated with performance in memory assessments. Prefrontal hemodynamics could distinguish aMCI and severe SMC from NC.
识别有发展为痴呆风险的个体对于早期干预至关重要。轻度认知障碍（MCI）和主观记忆主诉（SMC）被认为是其前期阶段。本研究旨在评估功能近红外光谱（fNIRS）在识别 MCI 和 SMC 个体中的效用。
将 151 名参与者分为正常认知（NC）；遗忘型 MCI（aMCI）；非遗忘型 MCI（naMCI）；轻度、中度和重度 SMC 组。在视觉记忆跨度任务中使用 fNIRS 测量任务相关的前额叶血液动力学。
结果显示，与 NC 相比，aMCI 组的氧合血红蛋白（HbO）水平显著降低，但 naMCI 组则不然。此外，重度 SMC 的 HbO 水平低于 NC、轻度和中度 SMC。受试者工作特征分析显示，aMCI 和重度 SMC 与 NC 分别具有 69.23%和 69.70%的区分准确率。
FNIRS 可能成为痴呆早期检测的潜在非侵入性生物标志物。
只有遗忘型轻度认知障碍（aMCI），而不是非遗忘型 MCI，表现出比正常人更低的氧合血红蛋白（HbO）。与 NC、轻度和中度 SMC 相比，重度 SMC 患者的 HbO 减少。前额叶血液动力学测量与记忆评估的表现相关。fNIRS 可以区分 aMCI 和重度 SMC 与 NC。
