Department of Urology, Sheba Medical Center, Tel-Hashomer, Israel.
The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Neurourol Urodyn. 2024 Nov;43(8):1809-1816. doi: 10.1002/nau.25521. Epub 2024 Jun 4.
To assess the association between overactive bladder syndrome (OAB) and the metabolic syndrome (MetS).
A population-based study was conducted to compare OAB patients with age-, sex- and ethnicity-matched control subjects regarding the prevalence of the parameters of the MetS, with respect to obesity, hyperlipidemia, hypertension and diabetes mellitus. The characteristics of the OAB population were assessed. Adjusted odds ratios (OR) were calculated by logistic regression.
110 024 OAB patients and 220 455 controls. were identified. OAB was associated with a higher prevalence of MetS (35.4% vs. 27.5%, p < 0.001). The fully adjusted OR for MetS in patients with OAB compared to controls was 1.44; 95% confidence interval (CI) 1.42-1.46; p < 0.001. Among metabolic parameters, obesity was found to be the strongest factor associated with OAB (OR 1.55, 95% CI 1.53-1.58, p < 0.001), and higher high-density lipoprotein cholesterole levels (>50) had a protective effect on the risk of OAB (OR 0.75, 95% CI 0.73-0.76, p < 0.001).
Data from this cohort suggest that OAB is positively associated with MetS. Clinicians approaching patients with OAB should be aware of this association. A multimodal treatment focusing on the MetS may be considered in these patients.
评估膀胱过度活动症（OAB）与代谢综合征（MetS）之间的关联。
进行了一项基于人群的研究，比较了 OAB 患者与年龄、性别和种族匹配的对照患者在代谢综合征参数方面的患病率，包括肥胖、血脂异常、高血压和糖尿病。评估了 OAB 人群的特征。通过逻辑回归计算了调整后的优势比（OR）。
确定了 110024 例 OAB 患者和 220455 例对照患者。OAB 与 MetS 的患病率较高相关（35.4%比 27.5%，p<0.001）。与对照组相比，OAB 患者发生 MetS 的调整后 OR 为 1.44；95%置信区间（CI）为 1.42-1.46；p<0.001。在代谢参数中，肥胖被认为是与 OAB 最相关的因素（OR 1.55，95%CI 1.53-1.58，p<0.001），而高密度脂蛋白胆固醇水平较高（>50）对 OAB 的风险具有保护作用（OR 0.75，95%CI 0.73-0.76，p<0.001）。
该队列数据表明，OAB 与 MetS 呈正相关。临床医生在治疗 OAB 患者时应注意到这种关联。在这些患者中，可以考虑采用一种针对 MetS 的多模式治疗。
