Khadour Fater A, Khadour Younes A, Alhatem Weaam, Barroush Deema Al, Xu Tao
Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Rehabilitation, Faculty of Medicine, Al Baath University, Homs, Syria.
Neurourol Urodyn. 2024 Nov;43(8):1835-1841. doi: 10.1002/nau.25567. Epub 2024 Jul 29.
The prevalence of overactive bladder (OAB) is known to be higher in patients with type 2 diabetes (T2DM) however there are not many studies about specific risk factors contributing to its progression among diabetes mellitus (DM) patients, so this study aimed to investigate the risk factors specific to DM that influence the progression of OAB in Syrian population.
This cross-sectional study was carried out at five endocrinology centers situated in four Syrian provinces: Damascus, Aleppo, Homs, Hama, and Latakia. The study comprised patients who were diagnosed with both T2DM and OAB and had visited these centers from March 2020 and February 2024. The Arabic version of the OAB Symptom Score (OABSS) scale was used to categorize the participants based on the severity score into two groups: the mild OAB group and the moderate-severe OAB group. A logistic analysis was conducted to assess the risk factors associated with the progression of OAB among patients with diabetes.
Among the 186 patients diagnosed with both DM and OAB, significant distinctions were found between the two groups concerning the severity of OAB, age, duration of diabetes, symptomatic diabetic peripheral neuropathy (DPN), and ankle reflex (p < 0.05). Furthermore, a multivariate analysis revealed that age (odds ratio [OR] 1.07, 95% confidence interval [CI] 0.68-1.58), duration of diabetes (OR 2.14, 95% CI 1.75-3.74), and symptomatic DPN (OR 2.47, 95% CI 1.17-3.54) independently acted as risk factors for the advancement of OAB.
The progression of OAB in Syrian patients with diabetes is closely associated with the severity of DM. Factors such as age, duration of diabetes, and symptomatic DPN are independent predictors of the severity of OAB. Patients who experience symptomatic DPN are at an increased risk of developing OAB.
已知2型糖尿病（T2DM）患者膀胱过度活动症（OAB）的患病率较高，然而，关于糖尿病（DM）患者中导致OAB进展的特定危险因素的研究并不多，因此本研究旨在调查影响叙利亚人群中OAB进展的糖尿病特异性危险因素。
这项横断面研究在叙利亚四个省份的五个内分泌中心进行：大马士革、阿勒颇、霍姆斯、哈马和拉塔基亚。该研究纳入了2020年3月至2024年2月期间在这些中心就诊的同时患有T2DM和OAB的患者。使用阿拉伯语版的OAB症状评分（OABSS）量表根据严重程度评分将参与者分为两组：轻度OAB组和中度 - 重度OAB组。进行逻辑分析以评估糖尿病患者中与OAB进展相关的危险因素。
在186例同时诊断为DM和OAB的患者中，两组在OAB严重程度、年龄、糖尿病病程、症状性糖尿病周围神经病变（DPN）和踝反射方面存在显著差异（p < 0.05）。此外，多变量分析显示年龄（优势比[OR] 1.07，95%置信区间[CI] 0.68 - 1.58）、糖尿病病程（OR 2.14，95% CI 1.75 - 3.74）和症状性DPN（OR 2.47，95% CI 1.17 - 3.54）独立地作为OAB进展的危险因素。
叙利亚糖尿病患者中OAB的进展与DM的严重程度密切相关。年龄、糖尿病病程和症状性DPN等因素是OAB严重程度的独立预测因素。出现症状性DPN的患者发生OAB的风险增加。
