卵巢内富含血小板血浆注射治疗卵巢反应不良。
Intraovarian platelet-rich plasma injection in poor responders.
机构信息
Procrearte, Buenos Aires, Argentina.
出版信息
JBRA Assist Reprod. 2024 Aug 26;28(3):450-456. doi: 10.5935/1518-0557.20240031.
OBJECTIVE
To evaluate if it possible to improve ovarian reserve parameters and oocyte retrieval in poor responders who undergo intraovarian injection of platelet-rich plasma (PRP).
METHODS
Prospective cohort study. We included 148 poor responders who underwent PRP injection between October 2021 and December 2022 in our institution, comparing pre and post PRP ovarian function. In addition, the IVF outcomes of a subgroup of patients was studied after the intervention in contrast with the previous treatment.
RESULTS
An improvement in ovarian reserve was observed in relation to previous values: FSH (13.57 vs. 11.32, p=0.11), AMH (0.39 vs. 0.48, p=0.06), antral follicle count (3.98 vs. 5.75, p<0.001); as well as a higher number of oocytes retrieved (2.63 vs. 3.65, p=0.01) and produced embryos (1.64 vs. 2.22, p=0.03); without a great impact on pregnancy rates.
CONCLUSIONS
Although experimental, intraovarian PRP could restore ovarian function and be postulated as an alternative to oocyte donation in patients with low ovarian reserve who do not accept this treatment. There is a lack of randomized controlled trials to support these findings.
目的
评估在卵巢储备功能不良的患者中行卵巢内注射富血小板血浆（PRP）是否可以改善卵巢储备参数和卵母细胞获取。
方法
前瞻性队列研究。我们纳入了 2021 年 10 月至 2022 年 12 月期间在我院行 PRP 注射的 148 例卵巢储备功能不良的患者，比较 PRP 注射前后的卵巢功能。此外，我们还研究了干预后部分患者的体外受精结局，并与之前的治疗进行了对比。
结果
与之前的值相比，卵巢储备有所改善：FSH（13.57 对 11.32，p=0.11）、AMH（0.39 对 0.48，p=0.06）、窦卵泡计数（3.98 对 5.75，p<0.001）；同时获得的卵母细胞数量（2.63 对 3.65，p=0.01）和产生的胚胎数量（1.64 对 2.22，p=0.03）也有所增加；但妊娠率没有显著提高。
结论
尽管这是一项实验性研究，但卵巢内 PRP 可能恢复卵巢功能，并可作为卵巢储备功能不良且不接受卵子捐赠治疗的患者的替代选择。目前缺乏支持这些发现的随机对照试验。
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