Panda Soumya R, Sachan Shikha, Hota Smrutismita
Obstetrics and Gynaecology, All India Institute of Medical Sciences, Mangalagiri, Guntur, IND.
Obstetrics and Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND.
Cureus. 2020 Dec 12;12(12):e12037. doi: 10.7759/cureus.12037.
The emergence of autologous platelet-rich plasma (PRP) therapy reflects a break-through for infertile patients with premature ovarian failure. To study the efficacy of intra-ovarian infusion of autologous PRP on the improvement of ovarian reserve parameters and the subsequent artificial reproductive technique (ART) cycle outcomes in infertile women with poor ovarian reserve or premature ovarian insufficiency, a systematic search in electronic databases like Medline (through PubMed), Embase, Scopus, Web of Science, and Cochrane was done using relevant search terms. Except for case series, case reports, and review articles, all other types of studies, those evaluated for the effects of intra-ovarian infusion of PRP in subfertile women for decreased ovarian reserve (DOR) or premature ovarian insufficiency (POI) were included in our systematic review. The data were extracted from each eligible study and cross-checked by two authors. Intra-ovarian PRP infusion appears to be effective in ovarian rejuvenation, and the results of the subsequent intracytoplasmic sperm injection (ICSI) cycle are encouraging. PRP intervention was found to be beneficial in terms of an improvement in ovarian reserve parameters (increase in serum anti-mullerian hormone or antral follicle count or decrease in serum follicular stimulating hormone). ICSI cycle performance in terms of the total number of oocytes retrieved, number of two-pronuclei embryos, fertilization rate, number of cleavage stage embryos, number of good quality embryos, and cycle cancellation rate were found to be improved after intra-ovarian PRP infusion as compared to their previous cycle without PRP infusion.
自体富血小板血浆（PRP）疗法的出现，为卵巢早衰的不孕患者带来了突破。为研究卵巢内注入自体PRP对改善卵巢储备功能参数以及后续对卵巢储备功能差或卵巢功能不全的不孕女性进行人工生殖技术（ART）周期结局的疗效，我们使用相关检索词在电子数据库如Medline（通过PubMed）、Embase、Scopus、Web of Science和Cochrane中进行了系统检索。除病例系列、病例报告和综述文章外，所有其他评估卵巢内注入PRP对卵巢储备功能下降（DOR）或卵巢功能不全（POI）的亚生育女性影响的研究类型均纳入我们的系统评价。数据从每项符合条件的研究中提取，并由两位作者进行交叉核对。卵巢内注入PRP似乎对卵巢功能恢复有效，且后续卵胞浆内单精子注射（ICSI）周期的结果令人鼓舞。发现PRP干预在改善卵巢储备功能参数方面有益（血清抗苗勒管激素增加或窦卵泡计数增加或血清促卵泡生成素降低）。与未注入PRP的前一周期相比，卵巢内注入PRP后，在获取的卵母细胞总数、双原核胚胎数、受精率、卵裂期胚胎数、优质胚胎数和周期取消率方面，ICSI周期表现得到改善。
