Respiratory Medicine, Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.
Clinical Toxicology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
J Med Toxicol. 2024 Jul 11;20(3):271-277. doi: 10.1007/s13181-024-01013-0. Epub 2024 Jun 5.
Synthetic cannabinoid receptor agonists (SCRAs) are associated with significant toxicity and are increasingly used in electronic vaping devices. We assessed the availability of SCRA vaping products to UK purchasers on the surface web.
An internet snapshot survey was performed between October 2022 and January 2023 on 'google.com' using the search terms "buy c-liquid vape", "buy herbal incense vape liquid", "buy cannabis vape liquid", "buy hashish vape liquid", "buy K2 vape liquid".
62 websites selling 128 SCRA vaping brands were identified. Most were purportedly based in the USA (41 websites, 66%) and most sold other controlled substances. Purchase incentives offered included discreet packaging (38, 61%), discounts for bulk purchase (34, 55%) and tracked delivery (30, 48%). Many websites stated SCRA products were: not for human consumption (41, 66%), for research purposes only (15, 24%), or legal (28, 45%). Websites sold a median (IQR) of 16 (7-25) SCRA vaping brands. Almost all were bottles of vaping liquid (1220/1225, 99.6%). The most common bottle size was 5mL (60%), the median (IQR) total volume of SCRA liquid per sale was 50mL (10-200mL). Median (IQR) price was £3.39/mL (£2.01/mL- £5.29/mL). Price decreased with increasing volume purchased (£6.58/mL for ≤ 5mL, £1.60/mL for > 200mL).
SCRA vaping products are easily obtainable online, in both small and bulk quantities. Information provided to purchasers on safety and legality is lacking or misleading. Further studies are needed to confirm the chemistry of these products. Policymakers should consider steps to limit the potential harm caused by the purchase and use of these products.
合成大麻素受体激动剂（SCRAs）与显著毒性相关，并且越来越多地被用于电子蒸气设备。我们评估了英国购买者在表面网络上获得 SCRAs 蒸气产品的情况。
2022 年 10 月至 2023 年 1 月期间，我们在“google.com”上使用了“购买 c-liquid vape”“购买草药焚香 vape 液体”“购买大麻 vape 液体”“购买大麻脂 vape 液体”“购买 K2 vape 液体”等搜索词进行了互联网快照调查。
共发现 62 个销售 128 个 SCRAs 蒸气品牌的网站。这些网站大多据称位于美国（41 个网站，66%），并且大多销售其他受控物质。提供的购买激励措施包括：保密包装（38，61%）、批量购买折扣（34，55%）和跟踪送货（30，48%）。许多网站声称 SCRAs 产品：不可供人类消费（41，66%）、仅供研究用途（15，24%）或合法（28，45%）。网站销售的 SCRAs 蒸气品牌中位数（IQR）为 16（7-25）个。几乎所有产品都是蒸气液体瓶（1220/1225，99.6%）。最常见的瓶身大小为 5mL（60%），每个销售的 SCRAs 液体总量中位数（IQR）为 50mL（10-200mL）。中位数（IQR）价格为 3.39 英镑/毫升（2.01 英镑/毫升-5.29 英镑/毫升）。随着购买量的增加，价格降低（5mL 时为 6.58 英镑/毫升，200mL 时为 1.60 英镑/毫升）。
SCRAs 蒸气产品可在线轻松获得，无论是小批量还是大批量。向购买者提供的关于安全性和合法性的信息要么缺失，要么具有误导性。需要进一步的研究来确认这些产品的化学成分。政策制定者应考虑采取措施限制购买和使用这些产品可能造成的潜在危害。
