Groupe de RMN Biomédicale, Laboratoire SPCMIB (UMR CNRS 5068), Université Paul Sabatier, Université de Toulouse, 118 route de Narbonne, Toulouse Cedex, 31062, France.
SCL, Laboratoire de Paris, 25 Avenue de la République, Massy, 91300, France.
Forensic Sci Int. 2021 Jul;324:110813. doi: 10.1016/j.forsciint.2021.110813. Epub 2021 May 8.
The H NMR profiles of 13 samples of e-liquids supplied by French customs were obtained with high-field and low-field NMR. The high-field H NMR spectra allowed the detection of matrix signals, synthetic cannabinoids, and flavouring compounds. Quantitative results were obtained for the five synthetic cannabinoids detected: JWH-210, 5F-MDMB-PICA, 5F-ADB, 5F-AKB48, and ADB-FUBINACA. Conventional GC-MS analysis was used to confirm compound identification. Fluorine-19 NMR was proposed for the quantification of fluorinated synthetic cannabinoids and was successfully implemented on both 400 MHz and 60 MHz NMR spectrometers. This study based on few examples explored the potentiality of low-field NMR for quantitative and quantitative analysis of synthetic cannabinoids in e-liquids.
法国海关提供的 13 个电子烟液样本的高场和低场 NMR 氢核磁共振图谱。高场氢核磁共振图谱可以检测基质信号、合成大麻素和调味化合物。对检测到的五种合成大麻素进行了定量分析：JWH-210、5F-MDMB-PICA、5F-ADB、5F-AKB48 和 ADB-FUBINACA。采用常规 GC-MS 分析对化合物进行鉴定。19F NMR 被提议用于定量分析含氟合成大麻素，并在 400 MHz 和 60 MHz NMR 光谱仪上成功实施。本研究基于少数几个例子，探索了低场 NMR 对电子烟液中合成大麻素进行定量和定量分析的潜力。
