Xi Pu, Huang Guizhong, Huang Kewei, Qin Dailei, Yao Zehui, Jiang Lingmin, Zhu Qi, He Chaobin
Department of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
State Key Laboratory of Oncology in South China, Department of Clinical Laboratory, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
J Inflamm Res. 2025 Jan 16;18:621-635. doi: 10.2147/JIR.S495815. eCollection 2025.
As a novel inflammatory-nutritional biomarker, the C-reactive protein-albumin-lymphocyte (CALLY) index has demonstrated significant prognostic value in various malignancies. However, research on its association with the prognosis of ampullary carcinoma (AC) is rare. This study aims to investigate the relationship between the CALLY index and the prognosis of patients with AC.
We retrospectively analyzed data from 201 patients with AC at Sun Yat-sen University Cancer Center. Several clinicopathological factors and biomarkers were included in the study. Univariate and multivariate Cox regression analyses, along with competing risk analysis, were performed to identify prognostic factors for AC after pancreaticoduodenectomy (PD). Only factors with significant results in univariate analysis were included in multivariate analysis. To ensure the robustness of our findings, propensity score matching (PSM) analyses were conducted to assess survival differences according to the CALLY index.
The univariate and multivariate Cox regression analyses revealed that pathological type, N stage, T stage, postoperative chemotherapy regimen, and the CALLY index were all statistically significant prognostic factors for patients with AC after PD (all P values < 0.05). Taking into account non-cancer-related mortality as competing hazards, these factors remained significant predictors (all P values < 0.05). After PSM, the survival advantage observed between the low and high CALLY groups remained discernible and consistent.
This study indicated that a reduced CALLY index correlates with a poorer cancer-specific survival in AC patients after PD, highlighting its utility as a prognostic marker for this condition.
作为一种新型的炎症-营养生物标志物，C反应蛋白-白蛋白-淋巴细胞（CALLY）指数已在多种恶性肿瘤中显示出显著的预后价值。然而，关于其与壶腹癌（AC）预后关系的研究却很少。本研究旨在探讨CALLY指数与AC患者预后之间的关系。
我们回顾性分析了中山大学肿瘤防治中心201例AC患者的数据。研究纳入了几个临床病理因素和生物标志物。进行单因素和多因素Cox回归分析以及竞争风险分析，以确定胰十二指肠切除术（PD）后AC的预后因素。多因素分析仅纳入单因素分析中有显著结果的因素。为确保研究结果的稳健性，进行倾向评分匹配（PSM）分析，以根据CALLY指数评估生存差异。
单因素和多因素Cox回归分析显示，病理类型、N分期、T分期、术后化疗方案以及CALLY指数均为PD后AC患者具有统计学意义的预后因素（所有P值<0.05）。将非癌症相关死亡率作为竞争风险考虑在内，这些因素仍然是显著的预测因素（所有P值<0.05）。PSM后，低CALLY组和高CALLY组之间观察到的生存优势仍然明显且一致。
本研究表明，CALLY指数降低与PD后AC患者较差的癌症特异性生存率相关，突出了其作为该疾病预后标志物的实用性。
