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槲寄生制剂的涡旋式与湍流混合对干燥液滴中形成的晶体结构产生影响。

Vortex-like vs. turbulent mixing of a Viscum album preparation affects crystalline structures formed in dried droplets.

作者信息

Kokornaczyk Maria Olga, Acuña Carlos, Mier Y Terán Alfonso, Castelán Mario, Baumgartner Stephan

机构信息

Society for Cancer Research, 4144, Arlesheim, Switzerland.

Institute for Complementary and Integrative Medicine, University of Bern, Freiburgstrasse 40, 3010, Bern, Switzerland.

出版信息

Sci Rep. 2024 Jun 5;14(1):12965. doi: 10.1038/s41598-024-63797-z.

Abstract

Various types of motion introduced into a solution can affect, among other factors, the alignment and positioning of molecules, the agglomeration of large molecules, oxidation processes, and the production of microparticles and microbubbles. We employed turbulent mixing vs. laminar flow induced by a vortex vs. diffusion-based mixing during the production of Viscum album Quercus L. 10 following the guidelines for manufacturing homeopathic preparations. The differently mixed preparation variants were analyzed using the droplet evaporation method. The crystalline structures formed in dried droplets were photographed and analyzed using computer-supported image analysis and deep learning. Computer-supported evaluation and deep learning revealed that the patterns of the variant succussed under turbulence are characterized by lower complexity, whereas those obtained from the vortex-mixed variant are characterized by greater complexity compared to the diffusion-based mixed control variant. The droplet evaporation method could provide a relatively inexpensive means of testing the effects of liquid flow and serve as an alternative to currently used methods.

摘要

引入溶液中的各种运动,在其他因素中,会影响分子的排列和定位、大分子的团聚、氧化过程以及微粒和微气泡的产生。我们按照顺势疗法制剂的生产指南,在制备欧洲槲寄生10时采用了湍流混合与由涡流诱导的层流以及基于扩散的混合方法。使用液滴蒸发法对不同混合方式的制剂变体进行分析。对干燥液滴中形成的晶体结构进行拍照,并使用计算机辅助图像分析和深度学习进行分析。计算机辅助评估和深度学习表明,在湍流条件下振荡的变体的图案复杂性较低,而与基于扩散的混合对照变体相比,由涡流混合变体获得的图案复杂性更高。液滴蒸发法可以提供一种相对廉价的测试液流效果的方法,并可作为当前使用方法的替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3abb/11153723/37c62d9e5c3a/41598_2024_63797_Fig1_HTML.jpg

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