Department of Clinical Laboratory, People's Hospital Affiliated of Fujian University of Traditional Chinese Medicine, Fuzhou, 350004, China.
Department of Preventive Medicine, People's Hospital Affiliated of Fujian University of Traditional Chinese Medicine, Fuzhou, 350004, China.
Virol J. 2024 Jun 5;21(1):129. doi: 10.1186/s12985-024-02393-z.
Global human activities were significantly impacted by the emergence of the coronavirus disease 2019 (COVID-19) pandemic caused by the 2019 novel coronavirus. This study aimed to investigate the prevalence and genotype distribution of HPV infection in Central Fujian Province during the pandemic.
Cervical samples were collected from 21,612 outpatients and 12,664 females who underwent physical examinations and HPV screening at the People's Hospital of Fujian Province in Fuzhou from April 2020 to April 2023. HPV detection and genotyping were conducted using PCR hybridization.
The overall HPV infection rate was 16.1% during the COVID-19 pandemic, with the outpatient group exhibiting a greater infection rate (19.0%) than did the healthy group (12.3%). The top five high-risk HPV (HR-HPV) genotypes in both groups were HPV52, HPV53, HPV58, HPV16, and HPV51. Additionally, HPV81 and HPV43 were the two most common low-risk HPV (LR-HPV) genotypes in the patient group, while HPV81 and HPV42 were the two most common LR-HPV genotypes in the healthy group. The highest prevalence of HPV infection was observed in individuals aged ≤ 24 years (28.4%, 95% CI 25.9-30.9), followed by those aged ≥ 55 years (23.6%, 95% CI 21.6-24.7) and other age groups. The prevalence decreased from 23.0% (95% CI 22.4-23.7) in 2018-2019 to 13.8% (95% CI 12.0-15.5) in 2023.
This study provides valuable insights into the prevalence and genotypes of HPV infection in the female population of Central Fujian Province from 2020 to 2023. The findings indicate that the prevalence of HPV infection in Central Fujian Province remains relatively low compared to the national average. Furthermore, the prevalence of HPV decreased during the COVID-19 pandemic; however, as the pandemic waned, there was potential for an increase in HPV infection rates. Therefore, it is crucial to strengthen HPV screening and vaccination strategies to prevent the potential spread of HPV.
由 2019 年新型冠状病毒引起的 2019 年冠状病毒病（COVID-19）大流行，对全球人类活动产生了重大影响。本研究旨在调查 COVID-19 大流行期间福建省中部地区 HPV 感染的流行率和基因型分布。
2020 年 4 月至 2023 年 4 月，从福建省人民医院接受体检和 HPV 筛查的 21612 名门诊患者和 12664 名女性中采集宫颈样本。采用 PCR 杂交法进行 HPV 检测和基因分型。
COVID-19 大流行期间，HPV 总感染率为 16.1%，门诊组感染率（19.0%）高于健康组（12.3%）。两组中前 5 位高危 HPV（HR-HPV）基因型均为 HPV52、HPV53、HPV58、HPV16 和 HPV51。此外，HPV81 和 HPV43 是患者组中两种最常见的低危 HPV（LR-HPV）基因型，HPV81 和 HPV42 是健康组中两种最常见的 LR-HPV 基因型。HPV 感染率最高的是年龄≤24 岁者（28.4%，95%CI 25.9-30.9），其次是年龄≥55 岁者（23.6%，95%CI 21.6-24.7）和其他年龄组。HPV 感染率从 2018-2019 年的 23.0%（95%CI 22.4-23.7）降至 2023 年的 13.8%（95%CI 12.0-15.5）。
本研究提供了 2020-2023 年福建省中部地区女性人群 HPV 感染的流行率和基因型的有价值信息。结果表明，福建省 HPV 感染率与全国平均水平相比仍然较低。此外，COVID-19 大流行期间 HPV 感染率下降，但随着大流行的结束，HPV 感染率有上升的可能。因此，加强 HPV 筛查和疫苗接种策略以预防 HPV 的潜在传播至关重要。
