Cochrane D D, Myles S T, Nimrod C, Still D K, Sugarman R G, Wittmann B K
Can J Neurol Sci. 1985 Feb;12(1):51-9. doi: 10.1017/s031716710004659x.
Advances in fetal diagnostic techniques have opened many areas to prenatal anatomical scrutiny. Intrauterine hydrocephalus and ventriculomegaly are conditions which are readily diagnosed. Fetal intervention has been undertaken in humans in order to minimize the craniofacial disfigurement and to maximize the growth potential of the brain. To justify such an approach, the significance of all anomalies should be recognized prior to treatment. The authors have reviewed 41 cases of hydrocephalus diagnosed in utero in order to define associated anomalies and patient outcome. 75% of our personal series and 72% of the reviewed literature cases had other anomalies of the central nervous system. Other system malformations, some of which proved fatal, were seen commonly. Prenatal diagnostic techniques did not always reveal these additional problems. The outcome of these pregnancies is not good. Approximately one third of these fetuses have survived to be treated postnatally and to be followed up clinically. Only 7.5% of this series were felt to have attained normal developmental milestones. The remainder of the survivors have various focal and/or global cerebral deficits.
胎儿诊断技术的进步为产前解剖学检查开辟了许多领域。宫内脑积水和脑室扩大是易于诊断的病症。为了尽量减少颅面畸形并最大限度地发挥大脑的生长潜力，已对人类进行了胎儿干预。为了证明这种方法的合理性，应在治疗前认识到所有异常的重要性。作者回顾了41例产前诊断为脑积水的病例，以确定相关异常和患者预后。我们个人系列中的75%以及文献综述病例中的72%存在中枢神经系统的其他异常。常见其他系统畸形，其中一些被证明是致命的。产前诊断技术并不总是能发现这些额外问题。这些妊娠的结局并不好。这些胎儿中约有三分之一存活至出生后接受治疗并进行临床随访。该系列中只有7.5%的胎儿被认为达到了正常发育里程碑。其余幸存者有各种局灶性和/或全身性脑功能缺陷。
