The Department of Endocrinology Children's Hospital of Capital Institute of Pediatrics, Beijing, China.
Front Endocrinol (Lausanne). 2024 May 22;15:1394347. doi: 10.3389/fendo.2024.1394347. eCollection 2024.
The association between 25(OH)D and pubertal timing has not been well studied. The aim of this study was to assess the relationship between 25(OH)D levels and pubertal timing in children.
Participants aged 6-14 years who had available nutritional and serum sex hormone (total testosterone (TT) and estradiol (E2)) information (n =1318) were included. We conducted a cross-sectional analysis of the associations between 25(OH)D and sex steroid hormones among children in the National Health and Nutrition Examination Survey, 2015-2016. Puberty was indicated by high levels of steroid hormones (TT≥50 ng/dL in men, E2≥20 pg/ml in women) or menarche.
Serum 25(OH)D and pubertal status showed the same trend in both males and females. In the male population, the OR values of serum 25(OH)D between 50 and <75 and ≥75 nmol/L were 0.52 (0.25, 1.08) and 0.64 (0.23, 1.75), respectively, compared with serum 25(OH)D<50 nmol/L. The OR of serum 25(OH)D ≥50 nmol/L compared with <50 nmol/L was 0.54 (0.26, 1.10), and the P value was statistically significant (P=0.048). In the female population, when the serum 25(OH)D concentration was <50 nmol/L, the ORs corresponding to a serum 25(OH)D concentration between 50 and <75 and ≥75 nmol/L were 0.53 (0.29, 0.98) and 0.50 (0.19, 1.30), respectively. The OR of serum 25(OH)D≥50 nmol/L compared with <50 nmol/L was 0.52 (0.19, 0.96), and the P value was statistically significant (P=0.037).
A lower 25(OH)D level was associated with earlier puberty in both girls and boys. There was a negative association between 25(OH)D concentrations and pubertal timing.
25（OH）D 与青春期开始的关系尚未得到很好的研究。本研究旨在评估儿童 25（OH）D 水平与青春期开始的关系。
纳入了年龄在 6-14 岁且有营养和血清性激素（总睾酮（TT）和雌二醇（E2））信息的参与者（n=1318）。我们对 2015-2016 年全国健康和营养检查调查中儿童的 25（OH）D 与性激素之间的关系进行了横断面分析。青春期通过高水平的类固醇激素（男性 TT≥50ng/dL，女性 E2≥20pg/ml）或初潮来表示。
血清 25（OH）D 和青春期状态在男性和女性中呈现出相同的趋势。在男性人群中，血清 25（OH）D 在 50-<75 和≥75nmol/L 之间的 OR 值分别为 0.52（0.25，1.08）和 0.64（0.23，1.75），与血清 25（OH）D<50nmol/L 相比。血清 25（OH）D≥50nmol/L 与<50nmol/L 相比的 OR 为 0.54（0.26，1.10），P 值具有统计学意义（P=0.048）。在女性人群中，当血清 25（OH）D 浓度<50nmol/L 时，血清 25（OH）D 浓度在 50-<75 和≥75nmol/L 之间对应的 OR 分别为 0.53（0.29，0.98）和 0.50（0.19，1.30）。血清 25（OH）D≥50nmol/L 与<50nmol/L 相比的 OR 为 0.52（0.19，0.96），P 值具有统计学意义（P=0.037）。
较低的 25（OH）D 水平与女孩和男孩的青春期提前有关。25（OH）D 浓度与青春期开始时间呈负相关。
