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全身 F-FDG PET 图像的自动肿瘤分割是否成为临床现实?

Is Automatic Tumor Segmentation on Whole-Body F-FDG PET Images a Clinical Reality?

机构信息

Quantitative Imaging and Medical Physics Team, Medical University of Vienna, Vienna, Austria

Quantitative Imaging and Medical Physics Team, Medical University of Vienna, Vienna, Austria.

出版信息

J Nucl Med. 2024 Jul 1;65(7):995-997. doi: 10.2967/jnumed.123.267183.

DOI:10.2967/jnumed.123.267183
PMID:38844359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11218718/
Abstract

The integration of automated whole-body tumor segmentation using F-FDG PET/CT images represents a pivotal shift in oncologic diagnostics, enhancing the precision and efficiency of tumor burden assessment. This editorial examines the transition toward automation, propelled by advancements in artificial intelligence, notably through deep learning techniques. We highlight the current availability of commercial tools and the academic efforts that have set the stage for these developments. Further, we comment on the challenges of data diversity, validation needs, and regulatory barriers. The role of metabolic tumor volume and total lesion glycolysis as vital metrics in cancer management underscores the significance of this evaluation. Despite promising progress, we call for increased collaboration across academia, clinical users, and industry to better realize the clinical benefits of automated segmentation, thus helping to streamline workflows and improve patient outcomes in oncology.

摘要

使用 F-FDG PET/CT 图像进行全自动全身肿瘤分割的整合代表了肿瘤诊断学的重大转变,提高了肿瘤负担评估的准确性和效率。这篇社论探讨了人工智能推动下的自动化发展,特别是通过深度学习技术。我们强调了商业工具的当前可用性以及为这些发展奠定基础的学术努力。此外,我们还评论了数据多样性、验证需求和监管障碍等挑战。代谢肿瘤体积和总病变糖酵解作为癌症管理的重要指标,突显了这种评估的重要性。尽管取得了有希望的进展,但我们呼吁学术界、临床用户和行业加强合作,以更好地实现自动化分割的临床效益,从而帮助简化工作流程并改善肿瘤学患者的治疗效果。

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本文引用的文献

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MONAI Label: A framework for AI-assisted interactive labeling of 3D medical images.MONAI Label:一个用于3D医学图像人工智能辅助交互式标注的框架。
Med Image Anal. 2024 Jul;95:103207. doi: 10.1016/j.media.2024.103207. Epub 2024 May 15.
2
Is F-FDG Metabolic Tumor Volume in Lymphoma Really Happening?淋巴瘤中的F-FDG代谢肿瘤体积真的存在吗?
J Nucl Med. 2024 Feb 22;65(4):510-1. doi: 10.2967/jnumed.123.267022.
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TMTV-Net: fully automated total metabolic tumor volume segmentation in lymphoma PET/CT images - a multi-center generalizability analysis.TMTV-Net:淋巴瘤PET/CT图像中全自动化的总代谢肿瘤体积分割——多中心可推广性分析
Eur J Nucl Med Mol Imaging. 2024 Jun;51(7):1937-1954. doi: 10.1007/s00259-024-06616-x. Epub 2024 Feb 8.
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Segment anything in medical images.在医学图像中分割任何内容。
Nat Commun. 2024 Jan 22;15(1):654. doi: 10.1038/s41467-024-44824-z.
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Developing, Purchasing, Implementing and Monitoring AI Tools in Radiology: Practical Considerations. A Multi-Society Statement from the ACR, CAR, ESR, RANZCR and RSNA.在放射科中开发、购买、实施和监测人工智能工具:实用考虑因素。ACR、CAR、ESR、RANZCR 和 RSNA 的多学会声明。
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TotalSegmentator: Robust Segmentation of 104 Anatomic Structures in CT Images.全段分割器:CT图像中104种解剖结构的稳健分割
Radiol Artif Intell. 2023 Jul 5;5(5):e230024. doi: 10.1148/ryai.230024. eCollection 2023 Sep.
7
Automatic Head and Neck Tumor segmentation and outcome prediction relying on FDG-PET/CT images: Findings from the second edition of the HECKTOR challenge.基于FDG-PET/CT图像的头颈部肿瘤自动分割及预后预测:HECKTOR挑战赛第二版的研究结果
Med Image Anal. 2023 Dec;90:102972. doi: 10.1016/j.media.2023.102972. Epub 2023 Sep 18.
8
A whole-body FDG-PET/CT Dataset with manually annotated Tumor Lesions.全身 FDG-PET/CT 数据集,带有手动标注的肿瘤病变。
Sci Data. 2022 Oct 4;9(1):601. doi: 10.1038/s41597-022-01718-3.
9
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10
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J Nucl Med. 2022 Sep;63(9):1288-1299. doi: 10.2967/jnumed.121.263239. Epub 2022 May 26.