Zisler Eva M, Meule Adrian, Koch Stefan, Voderholzer Ulrich
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Schoen Clinic Roseneck, Prien am Chiemsee, Germany.
Discov Ment Health. 2024 Jun 6;4(1):20. doi: 10.1007/s44192-024-00073-6.
Some persons with obsessive-compulsive disorder (OCD) refuse or drop out of treatment because of the aversive nature of exposure and response prevention therapy when they have to face and tolerate unpleasant thoughts, emotions, and bodily sensations. Indeed, one study suggested that a higher willingness to experience unpleasant thoughts, emotions, and bodily sensations (WTE) predicts a better treatment outcome, but this finding has not been replicated yet.
We examined whether WTE at admission predicted treatment outcome in a sample of 324 inpatients with OCD who received a multimodal treatment that included cognitive-behavioral therapy with exposure and response prevention sessions.
Obsessive-compulsive symptoms (based on OCD-specific self-report questionnaires) decreased with medium-to-large effect sizes (all ps < 0.001) and global functioning (based on therapist ratings) increased with a large effect size (d = 1.3, p < 0.001) from admission to discharge. In contrast to previous findings, however, WTE did not predict treatment outcome (all ps > 0.005). The effect of WTE on treatment outcome remained non-significant when controlling for any comorbidity, age, sex, length of stay, and antidepressant medication and was not moderated by these variables.
Results indicate that higher WTE at the beginning of inpatient treatment does not facilitate improvements in obsessive-compulsive symptoms from admission to discharge. However, they also indicate that lower WTE at the beginning of inpatient treatment does not adversely affect treatment outcome, that is, even patients who indicate that they are unwilling to face the negative experiences associated with exposure and response prevention can still achieve considerable symptom reductions.
一些强迫症(OCD)患者因暴露与反应阻止疗法具有厌恶性质而拒绝治疗或退出治疗,因为他们必须面对和忍受不愉快的想法、情绪及身体感觉。事实上,一项研究表明,更高的体验不愉快想法、情绪及身体感觉的意愿(WTE)预示着更好的治疗效果,但这一发现尚未得到重复验证。
我们在324例接受多模式治疗(包括有暴露与反应阻止环节的认知行为疗法)的强迫症住院患者样本中,研究入院时的WTE是否能预测治疗效果。
从入院到出院,强迫症状(基于强迫症特异性自我报告问卷)以中到较大效应量下降(所有p值<0.001),整体功能(基于治疗师评分)以较大效应量提升(d = 1.3,p<0.001)。然而,与之前的研究结果相反,WTE并不能预测治疗效果(所有p值>0.005)。在控制任何共病、年龄、性别、住院时间及抗抑郁药物后,WTE对治疗效果的影响仍不显著,且不受这些变量的调节。
结果表明,住院治疗开始时较高的WTE并不能促进从入院到出院期间强迫症状的改善。然而,结果也表明,住院治疗开始时较低的WTE不会对治疗效果产生不利影响,即,即使是那些表示不愿意面对与暴露和反应阻止相关的负面经历的患者,仍能实现相当程度的症状减轻。