Department of Nephrology, Hospital General Regional No.1, Instituto Mexicano del Seguro Social, Morelia, Mexico.
Facultad de Ciencias Médicas y Biológicas "Dr. Ignacio Chávez", Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mexico.
Ther Apher Dial. 2024 Dec;28(6):880-885. doi: 10.1111/1744-9987.14175. Epub 2024 Jun 7.
Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are markers of systemic inflammatory status. The relationship between NLR, PLR, and mortality is controversial among hemodialysis (HD) patients.
Evaluate NLR and PLR in the prediction of mortality in chronic HD patients.
We analyzed 130 patients with a follow-up for 66 months. Four groups were established according to NLR-PLR values. Kaplan-Meier curves and Cox proportional hazards analysis were used.
NLR-PLR correlated positively with C-reactive protein. Cox regression analysis for overall mortality among the four groups included age (HR 1.027, 95% CI 1.003-1.053) and albumin (HR 0.25, 95% CI 0.073-0.85). For cardiovascular (CV) mortality only pulse pressure differential (PPD) was included (HR 1.033; 95% CI 1.014-1.052). Low NLRs and high PLRs were associated with CV mortality (Log Rank test, p = 0.033).
Low NLRs and high PLRs predict the risk of CV mortality among HD patients.
中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）是全身炎症状态的标志物。在血液透析（HD）患者中，NLR 和 PLR 与死亡率之间的关系存在争议。
评估 NLR 和 PLR 在预测慢性 HD 患者死亡率中的作用。
我们分析了 130 例患者，随访时间为 66 个月。根据 NLR-PLR 值将患者分为四组。采用 Kaplan-Meier 曲线和 Cox 比例风险分析。
NLR-PLR 与 C 反应蛋白呈正相关。对四组患者全因死亡率的 Cox 回归分析包括年龄（HR 1.027，95%CI 1.003-1.053）和白蛋白（HR 0.25，95%CI 0.073-0.85）。对于心血管（CV）死亡率，仅包括脉压差（PPD）（HR 1.033；95%CI 1.014-1.052）。低 NLR 和高 PLR 与 CV 死亡率相关（Log Rank 检验，p=0.033）。
低 NLR 和高 PLR 可预测 HD 患者 CV 死亡率的风险。
