Desai Valay A, Momin Anjum M, Vaishnani Jignesh B
Department of Dermatology, Venereology and Leprology, Surat Municipal Institute of Medical Education and Research (SMIMER), Surat, Gujarat, India.
Indian Dermatol Online J. 2024 Apr 29;15(3):443-448. doi: 10.4103/idoj.idoj_774_23. eCollection 2024 May-Jun.
Vitiligo is an inveterate disease of great aesthetic concern presenting with depigmented macules and patches. It is often incorrigible to medical treatment.
To study the clinical profile of vitiligo patients and evaluate the effect of 5% 5-fluorouracil (5-FU) cream with microneedling.
This observational analytical study was conducted from November 2019 to July 2021. A total of 33 adult vitiligo patients were treated with oral mini-pulse (dexamethasone) therapy and topical corticosteroid (clobetasol propionate 0.05%). Patient's total number of vitiligo lesions with <10-cm size were counted and half of the lesions were treated with 5-FU + microneedling (Group A), while a remaining number of lesions were not treated with 5-FU + microneedling (Group B). In the case of the odd number of lesions, the total number of lesions minus one was considered and then divided into equal numbers for treatment. The procedure was performed every 2 weeks for 3 months. Clinical improvement was assessed monthly till 6 months by serial clinical photographs and grading scores.
Initiation of repigmentation started in the first month in Group A, whereas in Group B, it was seen in the second, which was statistically significant ( < 0.0001). Excellent improvement (>75% repigmentation) was noted in Group A as compared to Group B at the end of 6 months ( < 0.0001).
Needling with 5% 5-FU appears to be a simple, safe, and effective treatment in vitiligo. It can be used in poor responders to conventional therapy.
白癜风是一种令人极为关注美观问题的顽固性疾病，表现为色素脱失斑和斑块。其往往难以通过药物治疗治愈。
研究白癜风患者的临床特征，并评估5% 5-氟尿嘧啶（5-FU）乳膏联合微针治疗的效果。
本观察性分析研究于2019年11月至2021年7月进行。共有33例成年白癜风患者接受口服小剂量脉冲（地塞米松）疗法和外用糖皮质激素（0.05%丙酸氯倍他索）治疗。统计患者白癜风皮损总数，皮损大小<10 cm，其中一半皮损采用5-FU联合微针治疗（A组），其余皮损不采用5-FU联合微针治疗（B组）。若皮损数量为奇数，则考虑皮损总数减1，然后将其平均分为两组进行治疗。该操作每2周进行1次，共进行3个月。通过连续临床照片和分级评分每月评估临床改善情况，直至6个月。
A组在第1个月开始出现色素再生，而B组在第2个月出现，差异具有统计学意义（<0.0001）。6个月末，A组的改善情况优于B组（色素再生>75%），差异具有统计学意义（<0.0001）。
5% 5-FU微针治疗似乎是一种治疗白癜风的简单、安全且有效的方法。它可用于常规治疗效果不佳的患者。
