Tsuji T, Hamada T
Arch Dermatol. 1983 Sep;119(9):722-7.
In 28 patients with vitiligo, 5% fluorouracil cream was applied daily to vitiliginous lesions under occlusive dressings, following an epidermal abrasion on the first day. The treated lesions became completely eroded after seven to nine days of treatment at which time treatment was stopped. Epithelialization then occurred within ten days. Repigmentation first began one to two weeks after epithelialization and occurred in all the treated lesions within two months. Eighteen (64%) of the 28 patients showed complete or almost complete repigmentation in all treated spots and five patients (18%) showed partial repigmentation. The remaining five patients (18%), including two patients with segmental vitiligo, showed no response. Of 23 patients who showed complete or partial repigmentation, three patients had recurrence of vitiligo within one year. No systemic toxicity was observed in this series of patients.
在28例白癜风患者中，第一天进行表皮擦伤后，每天在白癜风皮损处涂抹5%氟尿嘧啶乳膏，并采用封闭敷料覆盖。治疗7至9天后，治疗部位完全糜烂，此时停止治疗。随后在10天内上皮化。色素再生在表皮化后1至2周开始，所有治疗部位在2个月内均出现色素再生。28例患者中有18例（64%）在所有治疗部位出现完全或几乎完全色素再生，5例患者（18%）出现部分色素再生。其余5例患者（18%），包括2例节段性白癜风患者，无反应。在23例出现完全或部分色素再生的患者中，3例患者在1年内白癜风复发。该系列患者未观察到全身毒性。
