Hamzavi Yazdan, Khodayari Mohammad Taghi, Davari Afshin, Shiee Mohammad Reza, Karamati Seyed Ahmad, Raeghi Saber, Jabarmanesh Hadis, Bashiri Helia, Bozorgomid Arezoo
Infectious Diseases Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Medical Parasitology and Mycology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Heliyon. 2024 May 25;10(11):e31955. doi: 10.1016/j.heliyon.2024.e31955. eCollection 2024 Jun 15.
Rodents are the largest group of mammals that adapt to different ecosystems and may act as the potential reservoirs of significant pathogens including gastrointestinal (GI) helminths. Rodent-borne parasitic pathogens have been and remain a great concern for animal and human health. The aim of this systematic review and meta-analysis is thus to clarify and better understand the pooled prevalence of GI helminthic infections and the associated risk factors in rodents in Iran. Multiple databases (PubMed, Scopus, Web of Science, Google Scholar, SID, Magiran and Irandoc) were searched for relevant literature published up to March 2022. A random-effects meta-analysis model was applied to estimate the pooled prevalence with 95 % confidence interval. Moreover, heterogeneity among studies was evaluated using the Cochran's test and the -statistic. Out of the 5438 publications searched, 28 articles (30 datasets) were ultimately eligible for inclusion in the study. Thus, 3649 captured rodents belonging to 6 families, 20 genera, and 35 species were examined for GI helminths in Iran. Then, 54 helminth species were identified in the present research, including 33 nematodes, 16 cestodes, 4 trematods, and 1 acanthocephalan. The prevalence rate of GI parasitic infections was 56 % (95 % CI: 50-63 %). , and were the most common helminthic infections (13 %, 9 %, and 8 %, respectively). Moreover, 11 potential zoonotic helminths were found. There was no significant difference in pooled prevalence between male and female rodents (P = 0.40). Considering geographical areas, northern and eastern provinces had the highest prevalence of GI helminthic infections among rodents. The prevalence of GI worms in Iranian rodents was as high as 56 % with 11 zoonotic helminths. Therefore, it is suggested to observe the health of the environment, destroy the biological nests of rodents, avoid half-finished constructions, repair and improve streams and sidewalks, organize and collect garbage, and carry out biological and chemical control to handle the population of rodents. Increasing the awareness of local people about the harmful effects of rodents and the ways of transmission and prevention of rodent-borne intestinal worms transmitted to humans should be prioritized in health decisions.
啮齿动物是适应不同生态系统的最大哺乳动物群体，可能充当包括胃肠道（GI）蠕虫在内的重要病原体的潜在宿主。啮齿动物传播的寄生虫病原体一直并仍然是动物和人类健康的重大关注点。因此，本系统评价和荟萃分析的目的是阐明并更好地了解伊朗啮齿动物胃肠道蠕虫感染的合并患病率及其相关危险因素。检索了多个数据库（PubMed、Scopus、科学网、谷歌学术、SID、Magiran和伊朗文献数据库），以查找截至2022年3月发表的相关文献。应用随机效应荟萃分析模型来估计合并患病率及其95%置信区间。此外，使用 Cochr an检验和I²统计量评估研究之间的异质性。在检索到的5438篇出版物中，最终有28篇文章（30个数据集）符合纳入研究的条件。因此，对伊朗境内捕获的属于6个科、20个属和35个物种的3649只啮齿动物进行了胃肠道蠕虫检查。然后，在本研究中鉴定出54种蠕虫，包括33种线虫、16种绦虫、4种吸虫和1种棘头虫。胃肠道寄生虫感染的患病率为56%（95%置信区间：50 - 63%）。 、 和 是最常见的蠕虫感染（分别为13%、9%和8%）。此外，还发现了11种潜在的人兽共患蠕虫。雄性和雌性啮齿动物的合并患病率没有显著差异（P = 0.40）。考虑到地理区域，北部和东部省份的啮齿动物胃肠道蠕虫感染患病率最高。伊朗啮齿动物中胃肠道蠕虫的患病率高达56%，有11种人兽共患蠕虫。因此，建议关注环境卫生，破坏啮齿动物的生物巢穴，避免未完工的建筑，修复和改善溪流及人行道，组织和收集垃圾，并进行生物和化学防治以控制啮齿动物数量。在卫生决策中，应优先提高当地居民对啮齿动物有害影响以及啮齿动物传播给人类的肠道蠕虫的传播和预防方式的认识。
