Kawamura Hitomi, Kishimoto Keiko
Division of Social Pharmacy, Department of Healthcare and Regulatory Sciences, Graduate School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
Department of Pharmacy, Tokyo Rosai Hospital, 4-13-21 Omoriminami, Ota-ku, Tokyo 143-0013, Japan.
PEC Innov. 2024 May 22;4:100293. doi: 10.1016/j.pecinn.2024.100293. eCollection 2024 Dec.
This study aimed to employ hypothetical models based on the protection motivation theory (PMT) to identify factors that improve the intention to use antibiotics appropriately (intention) among individuals who take antibiotics or administer them to their children.
Adult Japanese participants, including 600 parents who administer antibiotics to children aged <14 years and 600 adults who take them, completed an online survey. Structural equation modeling (SEM) was conducted on hypothetical models representing intention using 19 questions based on PMT. If the hypothesized model did not fit, SEM was repeated to search for a new model.
The hypothesized models did not fit. Two factors were extracted from SEM: "understanding the risk of antimicrobial resistance" and "excessive expectation of antibiotics." In adults, SEM revealed that "excessive expectation of antibiotics" (β = -0.50, < 0.001) negatively influenced intention; in children, "excessive expectation of antibiotics" (β = -0.52, < 0.001) negatively influenced intention, while "understanding the risk of antimicrobial resistance" (β = 0.22, < 0.001) positively influenced intention.
Factors influencing intention varied between adult and pediatric antibiotic use.
Awareness activities for appropriate antibiotic use should be tailored to population characteristics.
本研究旨在运用基于保护动机理论（PMT）的假设模型，确定在服用抗生素或给孩子使用抗生素的人群中，能提高合理使用抗生素意愿（意愿）的因素。
成年日本参与者，包括600名给14岁以下儿童使用抗生素的家长和600名服用抗生素的成年人，完成了一项在线调查。使用基于PMT的19个问题，对代表意愿的假设模型进行结构方程建模（SEM）。如果假设模型不拟合，则重复SEM以寻找新模型。
假设模型不拟合。从SEM中提取出两个因素：“了解抗菌药物耐药性风险”和“对抗生素期望过高”。在成年人中，SEM显示“对抗生素期望过高”（β = -0.50，<0.001）对意愿有负面影响；在儿童中，“对抗生素期望过高”（β = -0.52，<0.001）对意愿有负面影响，而“了解抗菌药物耐药性风险”（β = 0.22，<0.001）对意愿有正面影响。
影响成年人和儿童使用抗生素意愿的因素有所不同。
合理使用抗生素的宣传活动应根据人群特征进行调整。
