4D Convergence Technology Institute, Korea National University of Transportation, Jeungpyeong 27909, Republic of Korea; Department of Green Bioengineering, Korea National University of Transportation, Chungju 27470, Republic of Korea; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA, USA.
Department of IT and Energy Convergence (BK21 FOUR), Korea National University of Transportation, Chungju 27469, Republic of Korea.
J Control Release. 2024 Aug;372:1-30. doi: 10.1016/j.jconrel.2024.06.003. Epub 2024 Jun 13.
Breast cancer is the most prevalent cancer among women and the leading cause of cancer-related deaths in this population. Recent advances in Immunotherapy, or combined immunotherapy, offering a more targeted and less toxic approach, expand the survival rate of patients more than conventional treatment. Notably, hydrogels, a versatile platform provided promising avenues to combat breast cancer in preclinical studies and extended to clinical practices. With advantages such as the alternation of tumor microenvironment, immunomodulation, targeted delivery of therapeutic agents, and their sustained release at specific sites of interest, hydrogels can potentially be used for the treatment of breast cancer. This review highlights the advantages, mechanisms of action, stimuli-responsiveness properties, and recent advancements of hydrogels for treating breast cancer immunotherapy. Moreover, post-treatment and its clinical translations are discussed in this review. The integration of hydrogels in immunotherapy strategies may pave the way for more effective, personalized, and patient-friendly approaches to combat breast cancer, ultimately contributing to a brighter future for breast cancer patients.
乳腺癌是女性中最常见的癌症，也是该人群癌症相关死亡的主要原因。免疫疗法或联合免疫疗法的最新进展提供了一种更具针对性和更少毒性的方法，使患者的生存率超过了传统治疗。值得注意的是，水凝胶作为一种多功能平台，在临床前研究中为对抗乳腺癌提供了有前途的途径，并扩展到临床实践中。水凝胶具有改变肿瘤微环境、免疫调节、治疗剂的靶向递送以及在特定感兴趣部位的持续释放等优势，可用于治疗乳腺癌。本综述强调了水凝胶在治疗乳腺癌免疫疗法中的优势、作用机制、刺激响应特性和最新进展。此外，本综述还讨论了治疗后的情况及其临床转化。水凝胶在免疫治疗策略中的整合可能为更有效、个性化和患者友好的方法开辟道路，以对抗乳腺癌，最终为乳腺癌患者带来更美好的未来。
