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过敏性鼻炎的现行治疗方法。

Current Management of Allergic Rhinitis.

机构信息

Center for Rhinology and Allergology, Wiesbaden, Germany.

Department of Otorhinolaryngology, Hospital Clínic Barcelona, FRCB-IDIBAPS, CIBERES, University of Barcelona, Barcelona, Catalonia, Spain.

出版信息

J Allergy Clin Immunol Pract. 2024 Jun;12(6):1399-1412. doi: 10.1016/j.jaip.2024.03.023.

Abstract

Allergic rhinitis (AR) is the most common allergic disease worldwide and one of the most common chronic diseases in general. Allergic rhinitis is caused by inhalant allergens from outdoor and indoor environments with varying significance of different allergens in global regions. We provide options for the current management for AR including pharmacological treatments and nonpharmacological options and allergen immunotherapy (AIT). A literature review has been conducted in Medline, Pubmed, as well as the national and international study (ClinicalTrials.gov) and guideline registers and the Cochrane Library. Human studies published on the topic in the period up to and including November 2023 were taken into account. Allergen avoidance measures, pharmacotherapy, and AIT are the cornerstones of AR treatment. Nonpharmacological measures and behavioral recommendations should be adequately added. Tools of precision medicine are already playing a significant role and will be part of the diagnostic and therapeutic standard in the future. Patients benefit most in a network of different pharmacological and nonpharmacological treatment measures including AIT. Application of precision medicine tools for diagnosis and treatment will improve standards of care.

摘要

变应性鼻炎(AR)是全球最常见的过敏性疾病之一,也是最常见的慢性疾病之一。AR 由来自室外和室内环境的吸入性过敏原引起,不同地区过敏原的重要性不同。我们为 AR 的当前管理提供了一些选择,包括药物治疗和非药物选择以及变应原免疫治疗(AIT)。在 Medline、Pubmed 以及国家和国际研究(ClinicalTrials.gov)和指南登记处和 Cochrane 图书馆中进行了文献综述。考虑了截至 2023 年 11 月期间在该主题上发表的人类研究。变应原回避措施、药物治疗和 AIT 是 AR 治疗的基石。应充分添加非药物措施和行为建议。精准医学工具已经发挥了重要作用,并将成为未来诊断和治疗标准的一部分。患者在包括 AIT 在内的不同药物和非药物治疗措施网络中获益最多。应用精准医学工具进行诊断和治疗将提高护理标准。

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