Unoki Eye Clinic, Harara 1-7-15, Kagoshima City, Kagoshima, 890-0026, Japan.
Department of Ophthalmology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Sci Rep. 2024 Jun 9;14(1):13236. doi: 10.1038/s41598-024-63866-3.
This study aimed to evaluate visual function and perform multimodal imaging on patients with focal choroidal excavation without any chorioretinal disease (idiopathic focal choroidal excavation [iFCE]). Seventeen eyes of 15 patients with iFCE (8 men, 7 women; mean ± standard deviation age, 56.0 ± 10.8 years) were assessed for visual function including visual acuity, metamorphopsia, aniseikonia, and retinal sensitivity. Multimodal imaging included optical coherence tomography (OCT), fundus autofluorescence (FAF), and OCT angiography. This study found that the maximum width and depth of the excavation were 597 ± 330 (238-1809) µm and 123 ± 45 (66-231) µm, respectively, and that FAF showed normal or hypoautofluorescence corresponding to iFCE. The fundus examination findings were stable during the follow-up period (96 ± 48 months). None of the eyes showed any abnormalities in central retinal sensitivity or aniseikonia. Metamorphopsia was detected using Amsler grid testing and M-CHARTS in two eyes. Therefore, this study is the first to quantitatively and qualitatively study metamorphopsia of patients with iFCE. Our results showed that most patients with iFCE did not have visual impairments, despite the presence of morphological changes in the outer retina and choroid.
本研究旨在评估无任何脉络膜视网膜疾病（特发性局灶性脉络膜凹陷 [iFCE]）的局灶性脉络膜凹陷患者的视觉功能并进行多模态成像。评估了 15 例 iFCE 患者（8 名男性，7 名女性；平均年龄 ± 标准差为 56.0 ± 10.8 岁）的 17 只眼的视力功能，包括视力、变形、复视和视网膜敏感度。多模态成像包括光学相干断层扫描（OCT）、眼底自发荧光（FAF）和 OCT 血管造影。本研究发现，凹陷的最大宽度和深度分别为 597 ± 330（238-1809）μm 和 123 ± 45（66-231）μm，FAF 显示与 iFCE 相对应的正常或低自发荧光。在随访期间（96 ± 48 个月）眼底检查结果稳定。没有一只眼的中央视网膜敏感度或复视出现异常。在两只眼中使用 Amsler 网格测试和 M-CHARTS 检测到变形。因此，本研究首次对 iFCE 患者的变形进行了定量和定性研究。我们的结果表明，尽管外视网膜和脉络膜存在形态变化，但大多数 iFCE 患者的视力没有受损。
