Pierro L, Marchese A, Gagliardi M, Introini U, Battaglia Parodi M, Casalino G, Bandello F
Department of Ophthalmology, Scientific Institute San Raffaele, Vita-Salute University, Milan, Italy.
Eye (Lond). 2017 Dec;31(12):1740-1743. doi: 10.1038/eye.2017.136. Epub 2017 Jul 21.
PurposeTo describe multimodal imaging features of choroidal osteoma (CO) complicated by choroidal neovascularization (CNV) and focal choroidal excavation (FCE).MethodsPatients presenting with CO and CNV between January and October 2016 were considered for this study. Diagnosis of CO was confirmed by ultrasound examination. All patients underwent multimodal imaging including optical coherence tomography (OCT), swept-source OCT angiography (DRI OCT Triton, Topcon, Inc., Tokyo, Japan) and fluorescein angiography (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany).ResultsTwo patients (one with bilateral CO) were included in the study. OCT showed a FCE in two eyes of two patients (one in correspondence of the CNV and the other adjacent to the CNV). OCT-A demonstrated presence of microvascular flow within neovascular network of the CNVs. Decalcification of the tumor was noted in correspondence of one eye with FCE.ConclusionsFCE may be found in eyes with choroidal osteoma and CNV. OCT-A was a valuable tool for detection of CNV complicating choroidal osteoma. Decalcification of choroidal osteoma may represent a common pathogenic pathway for development of FCE and CNV in choroidal osteoma.
描述脉络膜骨瘤（CO）合并脉络膜新生血管（CNV）和局灶性脉络膜凹陷（FCE）的多模态成像特征。
本研究纳入2016年1月至10月期间出现CO和CNV的患者。通过超声检查确诊CO。所有患者均接受了多模态成像检查，包括光学相干断层扫描（OCT）、扫频源OCT血管造影（DRI OCT Triton，拓普康公司，日本东京）和荧光素血管造影（Spectralis HRA+OCT；海德堡工程公司，德国海德堡）。
两名患者（其中一名为双侧CO）纳入研究。OCT显示两名患者的两只眼中均有FCE（一只眼的FCE与CNV对应，另一只眼的FCE与CNV相邻）。OCT-A显示CNV的新生血管网络内存在微血管血流。在一只伴有FCE的眼中发现肿瘤有脱钙现象。
FCE可能出现在患有脉络膜骨瘤和CNV的眼中。OCT-A是检测脉络膜骨瘤合并CNV的重要工具。脉络膜骨瘤的脱钙可能是脉络膜骨瘤中FCE和CNV发生的常见致病途径。
