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岛叶皮层中突触前长时程增强所必需的皮质一氧化氮。

Cortical nitric oxide required for presynaptic long-term potentiation in the insular cortex.

机构信息

Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai , Chiyoda-ku, Tokyo 101-8310, Japan.

Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King's College Circle , Toronto, Ontario M5S 1A8, Canada.

出版信息

Philos Trans R Soc Lond B Biol Sci. 2024 Jul 29;379(1906):20230475. doi: 10.1098/rstb.2023.0475. Epub 2024 Jun 10.

DOI:10.1098/rstb.2023.0475
PMID:38853563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11343264/
Abstract

Nitric oxide (NO) is a key diffusible messenger in the mammalian brain. It has been proposed that NO may diffuse retrogradely into presynaptic terminals, contributing to the induction of hippocampal long-term potentiation (LTP). Here, we present novel evidence that NO is required for kainate receptor (KAR)-dependent presynaptic form of LTP (pre-LTP) in the adult insular cortex (IC). In the IC, we found that inhibition of NO synthase erased the maintenance of pre-LTP, while the induction of pre-LTP required the activation of KAR. Furthermore, NO is essential for pre-LTP induced between two pyramidal cells in the IC using the double patch-clamp recording. These results suggest that NO is required for homosynaptic pre-LTP in the IC. Our results present strong evidence for the critical roles of NO in pre-LTP in the IC. This article is part of a discussion meeting issue 'Long-term potentiation: 50 years on'.

摘要

一氧化氮（NO）是哺乳动物大脑中的一种关键扩散信使。有人提出，NO 可能逆行扩散到突触前末梢，有助于诱导海马长时程增强（LTP）。在这里，我们提出了新的证据，表明 NO 是成年脑岛皮层（IC）中依赖于 kainate 受体（KAR）的突触前形式的 LTP（pre-LTP）所必需的。在 IC 中，我们发现，NO 合酶的抑制消除了 pre-LTP 的维持，而 pre-LTP 的诱导需要 KAR 的激活。此外，使用双膜片钳记录，我们发现 NO 对于在 IC 中的两个锥体神经元之间诱导的 pre-LTP 是必不可少的。这些结果表明，NO 是 IC 中同突触 pre-LTP 所必需的。我们的结果为 NO 在 IC 中的 pre-LTP 中的关键作用提供了有力证据。本文是“长时程增强：50 年的讨论”专题讨论的一部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dcf/11343264/c225d1a15ef3/rstb.2023.0475.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dcf/11343264/08aa58d48bab/rstb.2023.0475.f001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dcf/11343264/c225d1a15ef3/rstb.2023.0475.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dcf/11343264/08aa58d48bab/rstb.2023.0475.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dcf/11343264/90ac47cae9eb/rstb.2023.0475.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dcf/11343264/df2c454a13e6/rstb.2023.0475.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dcf/11343264/e9beec74a141/rstb.2023.0475.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5dcf/11343264/c225d1a15ef3/rstb.2023.0475.f005.jpg

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Aversive state processing in the posterior insular cortex.后岛叶皮层中的厌恶状态处理。
Nat Neurosci. 2019 Sep;22(9):1424-1437. doi: 10.1038/s41593-019-0469-1. Epub 2019 Aug 27.
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Trigeminal Nerve Transection-Induced Neuroplastic Changes in the Somatosensory and Insular Cortices in a Rat Ectopic Pain Model.三叉神经切断术诱导大鼠异位痛模型中感觉和岛叶皮质的神经可塑性变化。
eNeuro. 2019 Jan 28;6(1). doi: 10.1523/ENEURO.0462-18.2019. eCollection 2019 Jan-Feb.
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Calcium-stimulated adenylyl cyclase subtype 1 (AC1) contributes to LTP in the insular cortex of adult mice.钙刺激的腺苷酸环化酶1型（AC1）有助于成年小鼠岛叶皮质中的长时程增强。
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