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Incremental induction of NMDAR-STP and NMDAR-LTP in the CA1 area of ventral hippocampal slices relies on graded activation of discrete NMDA receptors.在腹侧海马切片 CA1 区,NMDAR-STP 和 NMDAR-LTP 的逐渐诱导依赖于离散 NMDA 受体的分级激活。
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Differential effectiveness of dietary zinc supplementation with autism-related behaviours in knockout mice.膳食锌补充对自闭症相关行为的敲除小鼠的差异有效性。
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The plasticity of pyramidal neurons in the behaving brain.在行为大脑中,锥体神经元的可塑性。
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Rapidly reversible persistent long-term potentiation inhibition by patient-derived brain tau and amyloid ß proteins.患者源性脑tau 和淀粉样蛋白β 蛋白快速可逆的持久长时程增强抑制作用。
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Effect of dorsolateral prefrontal cortex structural measures on neuroplasticity and response to paired-associative stimulation in Alzheimer's dementia.背外侧前额叶皮层结构测量对阿尔茨海默病神经可塑性和对成对联想刺激反应的影响。
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Src dependency of the regulation of LTP by alternative splicing of exon 5.Src 依赖性调控 LTP 通过外显子 5 的选择性剪接。
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长时程增强:50 年历程:过去、现在和未来。

Long-term potentiation: 50 years on: past, present and future.

机构信息

Department of Psychology, Brain Health Research Centre, University of Otago, Dunedin 9054, New Zealand.

Group leader emeritus, The Francis Crick Institute, London NW1 1AT, UK.

出版信息

Philos Trans R Soc Lond B Biol Sci. 2024 Jul 29;379(1906):20230218. doi: 10.1098/rstb.2023.0218. Epub 2024 Jun 10.

DOI:10.1098/rstb.2023.0218
PMID:38853569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11343267/
Abstract

We introduce and summarize reviews and research papers by speakers at a discussion meeting on 'Long-term potentiation: 50 years on' held at the Royal Society, London, on 20-21 November 2023. The meeting followed earlier discussion meetings marking the 30th and 40th anniversaries of the discovery of long-term potentiation. These new contributions give an overview of current research and controversies in a vibrant branch of neuroscience with important implications for our understanding of the neurobiological basis of many forms of learning and memory and a wide spectrum of neurological and cognitive disorders.This article is part of a discussion meeting issue 'Long-term potentiation: 50 years on'.

摘要

我们介绍并总结了在 2023 年 11 月 20 日至 21 日于伦敦皇家学会举行的题为“长时程增强作用:50 年历程”的讨论会上的演讲者的评论和研究论文。该会议是继早前为纪念长时程增强作用发现 30 周年和 40 周年而举行的讨论会议之后召开的。这些新的贡献概述了当前神经科学领域一个充满活力的分支的研究和争议,对我们理解多种形式的学习和记忆以及广泛的神经和认知障碍的神经生物学基础具有重要意义。本文是“长时程增强作用:50 年历程”讨论会议专题的一部分。