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用于预防痴呆症的营养、运动和认知康复

Nutrition, Exercise, and Cognitive Rehabilitation for Dementia Prevention.

作者信息

Takakura Tomokazu

出版信息

Juntendo Iji Zasshi. 2024 Feb 16;70(1):9-22. doi: 10.14789/jmj.JMJ23-0032-R. eCollection 2024.

Abstract

Dementia is one of the most significant global challenges in medical and social care in the 21st century. It affects not only the patients themselves, but also their families, caregivers, and society in general, causing physical, psychological, and socioeconomic effects. As of 2020, there are approximately 6 million people in Japan aged 65 or older with dementia, and this number is expected to increase to around 7 million by 2025, meaning that one out of every five elderly people will have dementia. To prevent the onset and progression of dementia, it is crucial to have a proper understanding of its risks and adopt a healthy lifestyle. Leading an active life from an early stage can also aid in delaying or preventing the onset of dementia. Livingston has identified 12 risks that can lead to dementia, including physical inactivity, smoking, excessive alcohol consumption, air pollution, head injury, social isolation, poor educational history, obesity, hypertension, diabetes, depression, and hearing loss. Modifying one's lifestyle and leading an active life can be crucial in reducing these risks. The Mediterranean diet is gaining attention as a good practice for dementia prevention due to its diversity, richness in omega-3 fatty acids and vitamins. Exercise has been shown to prevent dementia on biological, behavioral, and socio-psychological levels. Repetitive transcranial magnetic stimulation is a non-invasive brain stimulation method that can alter brain plasticity and is being studied for clinical applications as a non-drug therapy for preventing dementia progression.

摘要

痴呆症是21世纪医学和社会护理领域最重大的全球性挑战之一。它不仅影响患者自身,还影响其家庭、护理人员以及整个社会,造成身体、心理和社会经济方面的影响。截至2020年,日本65岁及以上患有痴呆症的人数约为600万,预计到2025年这一数字将增至约700万,这意味着每五名老年人中就有一人会患痴呆症。为预防痴呆症的发生和发展,正确了解其风险并采取健康的生活方式至关重要。从早期就积极生活也有助于延缓或预防痴呆症的发生。利文斯顿确定了12种可能导致痴呆症的风险因素,包括缺乏身体活动、吸烟、过度饮酒、空气污染、头部受伤、社会孤立、教育经历不佳、肥胖、高血压、糖尿病、抑郁症和听力损失。改变生活方式并积极生活对于降低这些风险可能至关重要。地中海饮食因其多样性、富含欧米伽-3脂肪酸和维生素而作为预防痴呆症的良好做法受到关注。运动已被证明在生物学、行为学和社会心理学层面都能预防痴呆症。重复经颅磁刺激是一种非侵入性脑刺激方法,可改变大脑可塑性,目前正在作为预防痴呆症进展的非药物疗法进行临床应用研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd4a/11154644/08d9bec1c3f4/2188-2126-70-1-0009-g001.jpg

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