Grönroos M, Lehtonen A
Atherosclerosis. 1983 Apr;47(1):101-5. doi: 10.1016/0021-9150(83)90077-1.
The effect of high dose medroxyprogesterone (MPA) on serum lipids was studied in 31 postmenopausal patients with endometrial cancer. After 3 months of MPA treatment, total cholesterol decreased by 18% (P less than 0.001), LDL cholesterol by 16% (P less than 0.01) and HDL cholesterol by 38% (P less than 0.001) from the respective pretreatment values; correspondingly, the ratio of HDL to total cholesterol decreased (P less than 0.001). Similar changes were found as early as 2 weeks after start of treatment. In the 15 controls receiving no progestin treatment, full dose intracavitary radiotherapy and gynecological surgery had no effect on these serum lipids.
对31名绝经后子宫内膜癌患者研究了大剂量甲羟孕酮（MPA）对血脂的影响。MPA治疗3个月后，总胆固醇较各自治疗前值降低了18%（P<0.001），低密度脂蛋白胆固醇降低了16%（P<0.01），高密度脂蛋白胆固醇降低了38%（P<0.001）；相应地，高密度脂蛋白与总胆固醇的比值降低（P<0.001）。早在治疗开始2周后就发现了类似变化。在15名未接受孕激素治疗的对照者中，全量腔内放疗和妇科手术对这些血脂没有影响。
